42963-36-0

Basic information

• Product Name: 4,6-dimethyl-<1,2,5>oxadiazolo<3,4-d>pyrimidine-5,7(4H,6H)-dione 1-oxide
• Synonyms: 4,6-dimethyl-<1,2,5>oxadiazolo<3,4-d>pyrimidine-5,7(4H,6H)-dione 1-oxide
• CAS NO: 42963-36-0
• Molecular Weight: 198.138
• Mol File: 42963-36-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,6-dimethyl-<1,2,5>oxadiazolo<3,4-d>pyrimidine-5,7(4H,6H)-dione 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dimethyl-<1,2,5>oxadiazolo<3,4-d>pyrimidine-5,7(4H,6H)-dione 1-oxide(42963-36-0)
• EPA Substance Registry System: 4,6-dimethyl-<1,2,5>oxadiazolo<3,4-d>pyrimidine-5,7(4H,6H)-dione 1-oxide(42963-36-0)

Safety Data

• Hazardous Substances Data: 42963-36-0(Hazardous Substances Data)

Upstream product

• 3346-61-0 6-amino-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione 

Downstream Products

• 638-44-8 N,N'-(dithiodiethylene)bisacetamide 
• 70326-72-6 1,2,3,4-tetrahydro-1,3-dimethyl-5,7-diphenylpyrimido<4,5-d>pyrimidine-2,4-dione 
• 961-45-5 1,3-dimethyl-8-phenylxanthine 
• 2879-15-4 8-benzyltheophylline 
• 6439-85-6 1,3,7,9-tetramethyl-1H,9H-pyrimido[5,4-g]pteridine-2,4,6,8-tetraone 
• 33070-47-2 4,6-dimethyl[1,2,5]oxadiazolo[3,4-d]pyrimidine-5,7(4H,6H)-dione 

Relevant articles and documents

Facile synthesis and NO-generating property of 4H-[1, 2, 5]oxadiazolo[3, 4-d]pyrimidine-5, 7-dione 1-oxides

4H-[1, 2, 5]Oxadiazolo[3, 4-d]pyrimidine-5, 7-dione 1-oxides (2) are conveniently prepared in high yields by the oxidative intramolecular cyclization of 6-amino-5-mtro-lH-pyrimidine-2, 4-diones (1) employing iodosylbenzene diacetate as an oxidant in the presence of lithium hydride. The generation of nitric oxide (NO) and NO-related species from 2 occurs in the presence of thiols such as AT-acetylcysteamine, cysteine, and glutathione under physiological conditions. The evidence for the NO generation derives from mechanistic interpretations for the reaction of 2 with thiols and other chemical observations.