33468-72-3

Basic information

• Product Name: 1H-IMidazole, 2-(2-thienyl)-5-(trifluoroMethyl)-
• Synonyms: 1H-IMidazole, 2-(2-thienyl)-5-(trifluoroMethyl)-;2-(2-thienyl)-5-(trifluoromethyl)-1H-Imidazole
• CAS NO: 33468-72-3
• Molecular Formula: C8H5F3N2S
• Molecular Weight: 218.1989096
• Mol File: 33468-72-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 352.0±37.0 °C(Predicted)
• Appearance: /
• Density: 1.461±0.06 g/cm3(Predicted)
• PKA: 9.48±0.10(Predicted)
• CAS DataBase Reference: 1H-IMidazole, 2-(2-thienyl)-5-(trifluoroMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-IMidazole, 2-(2-thienyl)-5-(trifluoroMethyl)-(33468-72-3)
• EPA Substance Registry System: 1H-IMidazole, 2-(2-thienyl)-5-(trifluoroMethyl)-(33468-72-3)

Safety Data

• Hazardous Substances Data: 33468-72-3(Hazardous Substances Data)

Usage

General Description

1H-Imidazole, 2-(2-thienyl)-5-(trifluoromethyl)- is a chemical compound that contains an imidazole ring with a thienyl group at the 2-position and a trifluoromethyl group at the 5-position. It is a heterocyclic organic compound that is commonly used in pharmaceutical and medicinal chemistry as a building block for the synthesis of various pharmaceuticals, including anti-fungal agents, anti-parasitic drugs, and anti-cancer medications. The trifluoromethyl group contributes to the compound's hydrophobicity and lipophilicity, which can influence its pharmacokinetic properties. The compound's molecular structure makes it a versatile and valuable component in drug development and pharmaceutical research.

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 431-67-4 1,1-dibromo-3,3,3-trifluoroacetone 

Relevant articles and documents

Discovery of novel 2-aryl-4-bis-amide imidazoles (ABAI) as anti-inflammatory agents for the treatment of inflammatory bowel diseases (IBD)

A series of 2-Aryl-4-Bis-amide Imidazoles (ABAI-1 to 30) were designed as anti-inflammatory agents. These compounds were synthesized and evaluated for the in vitro anti-inflammatory activities (inhibition of NO production and release of inflammatory cytok

Synthesis and Cardiotonic Activity of Novel Biimidazoles

A series of substituted 2,2-bi-1H-imidazoles and related analogues was synthesized and evaluated for inotropic activity.Structure-activity relationship studies based on a nonclassical bioisosteric approach indicated the necessity of a cyano group on one o

2-Pyrazinyl-trifluoromethylimidazoles and a method for their preparation

4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammoni