33468-72-3

Usage

Uses

Used in Pharmaceutical Industry:
1H-Imidazole, 2-(2-thienyl)-5-(trifluoromethyl)is utilized as a key intermediate in the synthesis of various pharmaceuticals, including anti-fungal agents, anti-parasitic drugs, and anti-cancer medications. Its unique molecular structure allows for the development of drugs with enhanced efficacy and targeted action.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1H-Imidazole, 2-(2-thienyl)-5-(trifluoromethyl)is employed as a versatile component in the design and synthesis of novel therapeutic agents. Its properties contribute to the exploration of new drug candidates with improved pharmacokinetics and therapeutic potential.
Used in Drug Development:
1H-Imidazole, 2-(2-thienyl)-5-(trifluoromethyl)plays a crucial role in drug development, where it is used to create new chemical entities with potential applications in treating a variety of diseases. Its hydrophobicity and lipophilicity, conferred by the trifluoromethyl group, can influence the compound's absorption, distribution, metabolism, and excretion, which are critical factors in drug design.

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 431-67-4 1,1-dibromo-3,3,3-trifluoroacetone 

Relevant academic research and scientific papers

Discovery of novel 2-aryl-4-bis-amide imidazoles (ABAI) as anti-inflammatory agents for the treatment of inflammatory bowel diseases (IBD)

A series of 2-Aryl-4-Bis-amide Imidazoles (ABAI-1 to 30) were designed as anti-inflammatory agents. These compounds were synthesized and evaluated for the in vitro anti-inflammatory activities (inhibition of NO production and release of inflammatory cytok

BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF

The present disclosure provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled compounds, and prodrugs thereof. The provided compounds may be tumor necrosis factor ("TNF") receptor associated protein 1 ("TRAP1") modulators (e.g., TRAP1 activators). The provided compounds may also rescue the activity in PTEN-induced kinase 1 ("PINK1") loss of function contexts. The provided compounds may also improve mitochondrial health, function, quality, quantity, and/or activity, and/or reduce the production of reactive oxygen species. The provided compounds may also refold or solubilize aggregated or misfolded proteins such as α-synuclein. The present disclosure also provides pharmaceutical compositions comprising the provided compounds; kits comprising the provided compounds or pharmaceutical compositions; and methods of using the provided compounds and pharmaceutical compositions (e.g., for treating a disease in a subject in need thereof).

Synthesis and Cardiotonic Activity of Novel Biimidazoles

A series of substituted 2,2-bi-1H-imidazoles and related analogues was synthesized and evaluated for inotropic activity.Structure-activity relationship studies based on a nonclassical bioisosteric approach indicated the necessity of a cyano group on one o

Trifluoromethylimidazoles and a method for their preparation

4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammoni

2-Pyrazinyl-trifluoromethylimidazoles and a method for their preparation

4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammoni