33472-11-6

Usage

Uses

Used in Electronics Industry:
DIISOPROPYL HYDROXY(4-METHOXYPHENYL)METHYLPHOSPHONATE is used as a flame retardant for enhancing the fire safety of electronic components and devices. Its effectiveness and low toxicity make it a preferred choice over traditional flame retardants.
Used in Textile Industry:
In the textile industry, DIISOPROPYL HYDROXY(4-METHOXYPHENYL)METHYLPHOSPHONATE serves as a flame retardant to improve the fire resistance of fabrics and garments, ensuring safety and compliance with industry standards.
Used in Polymer Industry:
DIISOPROPYL HYDROXY(4-METHOXYPHENYL)METHYLPHOSPHONATE is utilized as a flame retardant in the production of various polymers, contributing to the development of safer and more durable materials for a wide range of applications.
Used as an Intermediate in Pharmaceutical and Agrochemical Synthesis:
DIISOPROPYL HYDROXY(4-METHOXYPHENYL)METHYLPHOSPHONATE also plays a crucial role as an intermediate in the synthesis of pharmaceuticals and agrochemicals, enabling the development of new and improved products in these industries.

Upstream product

• 1809-20-7 diisopropyl hydrogenphosphonate 
• 123-11-5 4-methoxy-benzaldehyde 
• 116-17-6 triisopropyl phosphite 
• 41097-21-6 diisopropyl (4-methoxybenzoyl)phosphonate 
• 2403-50-1 2-(4-methoxyphenyl)-1,3-dioxolane 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 1773-49-5 p-methoxybenzaldehyde 2,4-dinitrophenylhydrazone 

Relevant academic research and scientific papers

Synthesis and crystal structure of diisopropyl hydroxy(4-methoxyphenyl) methylphosphonate

The title compound, C14H23O5P, was synthesized by the reaction of 4-methoxybenzaldehyde and diisopropyl phosphite. Its structure was determined with X-ray crystallographic, NMR, MS, and elemental analysis (EA) techniques.

Utilization of 1,3-Dioxolanes in the Synthesis of α-branched Alkyl and Aryl 9-[2-(Phosphonomethoxy)Ethyl]Purines and Study of the Influence of α-branched Substitution for Potential Biological Activity

Syntheses of α-branched alkyl and aryl substituted 9-[2-(phosphonomethoxy)ethyl]purines from substituted 1,3-dioxolanes have been developed. Key synthetic precursors, α-substituted dialkyl [(2-hydroxyethoxy)methyl]phosphonates were prepared via Lewis acid mediated cleavage of 1,3-dioxolanes followed by reaction with dialkyl or trialkyl phosphites. The best preparative yields were achieved under conditions utilizing tin tetrachloride as Lewis acid and triisopropyl phosphite. Attachment of purine bases to dialkyl [(2-hydroxyethoxy)methyl]phosphonates was performed by Mitsunobu reaction. Final α-branched 9-[2-(phosphonomethoxy)ethyl]purines were tested for antiviral, cytostatic and antiparasitic activity, the latter one determined as inhibitory activity towards Plasmodium falciparum enzyme hypoxanthine-guanine-xanthine phosphoribosyltransfesase. In most cases biological activity was only marginal.

Copper-catalyzed synthesis of α-hydroxy phosphonates from H-phosphonates and alcohols or ethers

Easy PC: α-Hydroxy phosphonates were synthesized by copper/tert-butyl hydroperoxide (TBHP)-catalyzed oxidative addition reactions of H-phosphonates with alcohols or ethers. Diverse α-hydroxy phosphonates were obtained from substituted benzyl alcohols or alkyl alcohols and alkyl ethers in moderate to good yields. Copyright

Mechanistic approach for expeditious and solvent-free synthesis of α-hydroxy phosphonates using potassium phosphate as catalyst

An extremely simple, high yielding, highly rapid and solvent-free protocol has been described for hydrophosphylation of aldehydes using potassium phosphate as catalyst. Easy commercial availability of the reusable catalyst, operational simplicity at ambie

Synthesis, characterizations, and crystal structures of α-hydroxyphosphonic acid esters

This article describes the synthesis of -hydroxyphosphonic acid esters using the Pudovik reaction. IR, 1H NMR, 13C NMR, 31P NMR, MS, and elemental analysis were employed to confirm their structures. X-ray structure analysi

Asymmetric hydrogenation of α-keto phosphonates with chiral palladium catalysts

Under atmospheric hydrogen pressure, a catalytic amount of palladium(II) trifluoroacetate and (R)-MeO-BIPHEP in 2,2,2-trifluoroethanol promoted the asymmetric hydrogenation of diisopropyl α-keto phosphonates 1 to afford the corresponding α-hydroxy phospho

The preparation of dialkyl 1-hydroxyalkylphosphonates in the reaction of trialkyl phosphites with oxonium salts derived from aldehydes or ketones

The reaction of trialkyl phosphites with aldehydes or ketones in the presence of hydrogen chloride gives dialkyl 1-hydroxyalkylphosphonates via Arbusov-like reaction of oxonium salts derived from aldehydes or ketones. This reaction is a very convenient instant method for the preparation of dialkyl 1-hydroxyalkylphosphonates with a good yield as an alternative to the well-known Abramov reaction. Georg Thieme Verlag Stuttgart.