334832-89-2

Basic information

• Product Name: 1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-4-hydroxy-, hydrazide
• CAS NO: 334832-89-2
• Molecular Formula: C10H9ClN4O2
• Molecular Weight: 252.66
• Mol File: 334832-89-2.mol

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-4-hydroxy-, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-4-hydroxy-, hydrazide(334832-89-2)
• EPA Substance Registry System: 1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-4-hydroxy-, hydrazide(334832-89-2)

Safety Data

• Hazardous Substances Data: 334832-89-2(Hazardous Substances Data)

Usage

Molecular structure

A pyrazole ring with a carboxylic acid group, a chlorophenyl group, a hydroxy group, and a hydrazide functional group.

Pharmacological properties

PHCH has potential as an anti-tumor agent, in the treatment of inflammatory diseases, and as an antibacterial agent.

Industrial uses

PHCH has been investigated as an intermediate in the synthesis of other pharmaceutical compounds.

Other notes

PHCH is a chemical compound that requires further research and development to fully understand its potential uses and applications.

Upstream product

• 26502-56-7 ethyl 4-hydroxy-1-(4-chlorophenyl)-1H-pyrazole-3-carboxylate 

Downstream Products

• 1226775-07-0 3-(3,5-dioxopyrazolidin-1-yl)carbonyl-1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole 
• 1226775-04-7 3-(5-methyl-3-phenyl-1H-pyrazol-1-yl)carbonyl-1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole 
• 1226775-10-5 3-(3,5-dioxo-4-phenylpyrazolidin-1-yl)carbonyl-1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole 
• 1226775-09-2 3-(4-butyl-3,5-dioxopyrazolidin-1-yl)carbonyl-1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole 
• 1226775-08-1 3-(4-ethyl-3,5-dioxopyrazolidin-1-yl)carbonyl-1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole 
• 1226775-12-7 3-(3-oxo-1,2,5,6-tetrahydrocyclopenta[c]pyrazol-2-yl)carbonyl-1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole 
• 1226775-02-5 3-(4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)carbonyl-1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole 
• 1226775-21-8 1-(4-chlorophenyl)-4-hydroxy-3-((2-oxoindolin-3-ylidene)hydrazinocarbonyl)-1H-pyrazole 
• 1226775-06-9 3-(3-(2-furyl)-5-trifluoromethyl-1H-pyrazol-1-yl)carbonyl-1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole 
• 1226775-20-7 1-(4-chlorophenyl)-N-(3,4-dihydro-1-oxo-1H-pyrido[3,4-b]indol-2(9H)-yl)-4-hydroxy-1H-pyrazole-3-carboxamide 
• 1226775-19-4 1-(4-chlorophenyl)-4-hydroxy-N-(2-methyl-4-oxoquinazolin-3(4H)-yl)-1H-pyrazole-3-carboxamide 
• 1226775-18-3 N-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxamide 
• 1226775-11-6 3-(1,2-dihydro-5-(2-hydroxyethyl)-4-methyl-3-oxopyrazol-2-yl)carbonyl-1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole 
• 1226775-13-8 3-(3-methyl-4,5-dihydronaphtho[1,2-c]pyrazol-2-yl)carbonyl-1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole 

Relevant articles and documents

Polysubstituted pyrazoles, Part 4: Synthesis, antimicrobial and antiinflammatory activity of some pyrazoles

As a continuation of an earlier interest in polysubstituted pyrazoles, the synthesis of some derivatives of 1H-pyrazol-4-yl-2-oxo-but-3-enoic acid and ethyl 4-hydroxy-1H-pyrazole-3-carboxylates of potential antimicrobial and antiinflammatory activity is described. One compound showed in vitro antibacterial activity and two compounds displayed in vivo antiinflammatory potency in rats.