334887-46-6Relevant articles and documents
Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors
Madsen,Br?uner-Osborne,Frydenvang,Hvene,Johansen,Nielsen,Sánchez,Stensb?l,Bischoff,Krogsgaard-Larsen
, p. 1051 - 1059 (2007/10/03)
Using ibotenic acid (2) as a lead, two series of 3-isoxazolol amino acid ligands for (S)-glutamic acid (Glu, 1) receptors have been developed. Whereas analogues of (RS)-2-amino-3-(3-hydroxy- 5-methyl-4-isoxazolyl)propionic acid [AMPA, (RS)-3] interact sel