33490-73-2

Upstream product

• 33490-71-0 [2-(3,4-Dimethoxy-benzyl)-4,5-dimethoxy-phenyl]-acetonitrile 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 154502-82-6 1-(3,4-dimethoxyphenyl)-1,4-dihydro-6,7-dimethoxy-3H-2-benzopyran-3-one 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 16135-41-4 6,7-dimethoxy-3,4-dihydro-1H-2-benzopyran-3-one 
• 91-16-7 1,2-dimethoxybenzene 

Downstream Products

• 82072-02-4 3,4-Dimethoxy-6-(3,4-dimethoxybenzyl)phenylacetone 
• 33490-74-3 2-[2-(3,4-Dimethoxy-benzyl)-4,5-dimethoxy-phenyl]-N,N-dimethyl-acetamide 
• 70557-96-9 Acetic acid 2,3,7,8-tetramethoxy-5H-dibenzo[a,d]cyclohepten-10-yl ester 
• 33602-25-4 {2-[2-(3,4-Dimethoxy-benzyl)-4,5-dimethoxy-phenyl]-ethyl}-dimethyl-amine 

Relevant academic research and scientific papers

New MT2 melatonin receptor-selective ligands: Agonists and partial agonists

The search for melatonin receptor agonists and antagonists specific towards one of the receptor subtypes will extend our understanding of the role of this system in relaying circadian information to the body. A series of compounds derived from a hit compound discovered in a screening process led to powerful agonists specific for one of the isoform of the melatonin receptor namely, MT2. The compounds are based on a poorly explored skeleton in the molecular pharmacology of melatonin. By changing the steric hindrance of one substituent (i.e., from a hydrogen atom to a tributylstannyl group), we identified a possible partial agonist that could lead to antagonist analogues. The functionalities of these compounds were measured with a series of assays, including the binding of GTPγS, the inhibition of the cyclic AMP production, the β-arrestin recruitment, and the cell shape changes as determined by cellular dielectric spectroscopy (CellKey). The variations between the compounds are discussed.

Trifluoroacetic Anhydride Mediated One-Pot Synthesis of 1-Aryl Isochroman-3-ones via the Carboxy-Pictet-Spengler Reaction

In this paper, a novel and open-vessel route for the facile-operational synthesis of 1-aryl isochroman-3-ones is described via (CF3CO)2O (trifluoroacetic anhydride, TFAA)-mediated intermolecular (4 + 2) annulation of oxygenated arylacetic acids with arylaldehydes or ketones under mild reaction conditions. A plausible mechanism is proposed and discussed herein. Various reaction conditions are investigated for efficient transformation under an environmentally friendly one-pot carboxy-Pictet-Spengler reaction.