33493-30-0Relevant academic research and scientific papers
One-pot synthesis of phosphinylphosphonate derivatives and their anti-tumor evaluations
Deschamp, Julia,Dussart-Gautheret, Jade,Lecouvey, Marc,Legigan, Thibaut,Migianu-Griffoni, Evelyne,Monteil, Maelle
, (2021/12/24)
This paper reports on the synthesis of new hydroxymethylene-(phosphinyl)phosphonates (HMPPs). A methodology has been developed to propose an optimized one-pot procedure without any intermediate purifications. Various aliphatic and (hetero)aromatic HMPPs were synthesized in good to excellent yields (53–98%) and the influence of electron withdrawing/donating group substitution on aromatic substrates was studied. In addition, the one-pot synthesis of HMPP was monitored by31P NMR spectroscopy, allowing effective control of the end of the reaction and identification of all phosphorylated intermediate species, which enabled us to propose a reaction mechanism. Optimized experimental conditions were applied to the preparation of biological relevant aminoalkyl-HMPPs. A preliminary study of the complexation to hydroxyapatite (bone matrix) was carried out in order to verify its lower affinity towards bone compared to bisphosphonate molecules. Moreover, in vitro anti-tumor activity study revealed encouraging antiproliferative activities on three human cancer cell lines (breast, pancreas and lung).
Geminal difunctionalization of α-diazo arylmethylphosphonates: Synthesis of fluorinated phosphonates
Zhou, Yujing,Zhang, Yan,Wang, Jianbo
, p. 10444 - 10453 (2016/11/18)
A general approach towards diverse fluorinated phosphonates via geminal difunctionalization reactions of α-diazo arylmethylphosphonates is described. The diazo functionality (RR′CN2) is successfully converted to RR′CF2, RR′CHF, RR′CFBr or RR′CFNR′′2 groups by employing different fluorination reagents. A variety of fluorinated organophosphorus compounds were readily accessed in good to excellent yields from a common type of precursor.
Reactions of acyl phosphonates with organoaluminum reagents: A new method for the synthesis of secondary and tertiary α-hydroxy phosphonates
Seven, Ozlem,Polat-Cakir, Sidika,Hossain, Md. Shakhawoat,Emrullahoglu, Mustafa,Demir, Ayhan S.
body text, p. 3464 - 3469 (2011/06/19)
The reactions of organoaluminum reagents (trimethylaluminum, triethylaluminum, etc.) with aryl and alkyl acyl phosphonates, which lead to the formation of α-hydroxy phosphonates in moderate to good yields, are reported. This method provides easy access to
One-pot synthesis of 1-hydroxymethylene-1,1-bisphosphonate partial esters
Migianu, Evelyne,Mallard, Isabelle,Bouchemal, Nadia,Lecouvey, Marc
, p. 4511 - 4513 (2007/10/03)
A selective one-pot procedure of synthesis of 1-hydroxymethylene-1,1- bisphosphonic partial trimethylesters and P,P-, P,P′-diesters was described.
Novel Quasiphosphonium Ylides from the Reaction of Trialkyl Phosphites with Dialkyl Benzoylphosphonates: Evidence for Carbene Intermediates in the Intramolecular Cyclisation of 2-Substituted Dialkyl Benzoylphosphonates
Griffiths, D. Vaughan,Griffiths, Penelope A.,Whitehead, Belinda J.,Tebby, John C.
, p. 479 - 484 (2007/10/02)
The reaction of dialkyl aroylphosphonates 1 with trialkyl phosphites leads to the formation of novel quasiphosphonium ylides 4 which in some cases thermally rearrange to the bisphosphonates 5. 2-Substituted dialkyl aroylphosphonates may also undergo intra
gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity
Nguyen,Niesor,Bentzen
, p. 1426 - 1433 (2007/10/02)
New diphosphonate compounds and related derivatives were synthesized and investigated for their activity in specifically inducing plasma high density lipoproteins (HDL) and high density lipoprotein cholesterol (HDL-C) in normal rats. The screening of nume
