33496-82-1

Upstream product

• 78-59-1 3,5,5-Trimethylcyclohex-2-en-1-one 
• 67217-68-9 1,1-dimethoxy-3,3,5-trimethyl-cyclohexane 
• 873-94-9 dihydroisophorone 
• 147-85-3 L-proline 

Relevant academic research and scientific papers

CATALYTIC ASYMMETRIC HYDROGENATION OF α-β-UNSATURATED KETONES USING CHIRAL RUTHENIUM HYDRIDE COMPLEXES.

Chiral ruthenium hydrides : HRuCl(TBPC)2 and H2Ru(TBPC)2 catalyse the hydrogenation of α-β-unsaturated ketones to ketones (e.e. 62 percent).

Sonochemical asymmetric hydrogenation of isophorone on proline modified Pd/Al2O3 catalysts.

The sonochemical asymmetric hydrogenation of isophorone (3,3,5-trimethyl-2-cyclohexenone) by proline-modified Pd/Al2O3 catalysts is described; presonication of a commercial Pd/Al2O3-proline catalytic system resulted in highly enhanced enantioselectivities

Heterogeneously catalyzed asymmetric hydrogenation of C=C bonds directed by surface-tethered chiral modifiers

Asymmetric hydrogenation of C=C bonds is of the highest importance in organic synthesis, and such reactions are currently carried out with organometallic homogeneous catalysts. Achieving heterogeneous metal-catalyzed hydrogenation, a highly desirable goal

Copper-catalyzed reductive alkylations of enones: A novel transmetalation protocol

Looking for an alternative to prepare your regio- and stereodefined boron enolates? Concerned about using expensive and moisture-sensitive Bu2BOTf? Consider this new procedure for regiospecific enolization based on a catalytic CuH-initiated 1,4

Stereodifferentiation in heterogeneous catalytic hydrogenation. Kinetic resolution and asymmetric hydrogenation in the presence of (S)-proline: Catalyst-dependent processes

The kinetic resolution of 3,5,5-trimethyl cyclohexanone (TMCH) and asymmetric hydrogenation of isophorone (3,5,5-trimethyl cyclohex-2-enone, IP) were investigated on different Pd catalysts in the presence of (S)-proline (Pr). It could be proven that in isophorone hydrogenation the optically active TMCH was formed not only by kinetic resolution but also through asymmetric C{double bond, long}C hydrogenation. The activity and stereoselectivity of different Pd catalysts depended on the support material, preparation method, and reaction conditions as well, confirming our assumption that enantiodifferentiation takes also place on the catalyst surface and not only in the homogeneous liquid phase condensation reaction.

Enantioselection on Heterogeneous Noble Metal Catalyst: Proline-Induced Asymmetry in the Hydrogenation of Isophorone on Pd Catalyst

In the (S)-proline-mediated asymmetric hydrogenation of isophorone (IP) on supported Pd catalyst, excellent enantioselectivity is achieved, with an enantiomeric excess of up to 99%. The role of the heterogeneous catalyst has been the subject of a controve

New P-chirogenic tert.-butyl-xantphos ligands and their application in asymmetric hydrogenation and alkylation

The synthesis of a broad library of new P-chirogenic Xantphos ligands is reported. A special feature is 2,7-di-tert.-butyl substituents in the backbone which requires the modification of the original synthetic approach. In comparison to related ligands reported formerly the substitution has a considerable influence on the results (yield and % e.e.) of metal catalyzed reactions, e.g. asymmetric rhodium catalyzed hydrogenation of isophorone and the palladium catalyzed alkylation, respectively.

Enantio- A nd regioselective: Ene-reductions using F420H2-dependent enzymes

In the past decade it has become clear that many microbes harbor enzymes that employ an unusual flavin cofactor, the F420 deazaflavin cofactor. Herein we show that F420-dependent reductases (FDRs) can successfully perform enantio-, regio- A nd chemoselective ene-reductions. For the first time, we have demonstrated that F420H2-driven reductases can be used as biocatalysts for the reduction of α,β-unsaturated ketones and aldehydes with good conversions (>99%) and excellent regioselectivities and enantiomeric excesses (>99% ee). Noteworthily, FDRs typically display an opposite enantioselectivity when compared to the well established FMN-dependent Old Yellow Enzymes (OYEs).

A process for preparing optically active aldehyde or ketone method (by machine translation)

The present invention provides an asymmetric hydrogenation process for preparing optically active aldehyde or ketone of the method. The invention using transition metal catalyst and amino acid ester catalyst, so that the α, β - unsaturated aldehyde or ketone by selective asymmetric hydrogenation and the preparation of optically active aldehyde or ketone, reaction selectivity is greatly improved, the optical purity of the product can be as high as 99ee %. (by machine translation)

MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.