33496-82-1Relevant articles and documents
CATALYTIC ASYMMETRIC HYDROGENATION OF α-β-UNSATURATED KETONES USING CHIRAL RUTHENIUM HYDRIDE COMPLEXES.
Massonneau, Viviane,le Maux, Paul,Simonneaux, Gerard
, p. 5497 - 5498 (1986)
Chiral ruthenium hydrides : HRuCl(TBPC)2 and H2Ru(TBPC)2 catalyse the hydrogenation of α-β-unsaturated ketones to ketones (e.e. 62 percent).
Heterogeneously catalyzed asymmetric hydrogenation of C=C bonds directed by surface-tethered chiral modifiers
Watson, David J.,Jesudason, R. J. Bennie Ram John,Beaumont, Simon K.,Kyriakou, Georgios,Burton, Jonathan W.,Lambert, Richard M.
, p. 14584 - 14589 (2009)
Asymmetric hydrogenation of C=C bonds is of the highest importance in organic synthesis, and such reactions are currently carried out with organometallic homogeneous catalysts. Achieving heterogeneous metal-catalyzed hydrogenation, a highly desirable goal
Stereodifferentiation in heterogeneous catalytic hydrogenation. Kinetic resolution and asymmetric hydrogenation in the presence of (S)-proline: Catalyst-dependent processes
Gyorffy, Nora,Tungler, Antal,Fodor, Matyas
, p. 2 - 8 (2010)
The kinetic resolution of 3,5,5-trimethyl cyclohexanone (TMCH) and asymmetric hydrogenation of isophorone (3,5,5-trimethyl cyclohex-2-enone, IP) were investigated on different Pd catalysts in the presence of (S)-proline (Pr). It could be proven that in isophorone hydrogenation the optically active TMCH was formed not only by kinetic resolution but also through asymmetric C{double bond, long}C hydrogenation. The activity and stereoselectivity of different Pd catalysts depended on the support material, preparation method, and reaction conditions as well, confirming our assumption that enantiodifferentiation takes also place on the catalyst surface and not only in the homogeneous liquid phase condensation reaction.
New P-chirogenic tert.-butyl-xantphos ligands and their application in asymmetric hydrogenation and alkylation
B?rner, Armin,Gandelman, Mark,Holz, Jens,Spannenberg, Anke,Wenzel, Gudrun
, (2020/03/25)
The synthesis of a broad library of new P-chirogenic Xantphos ligands is reported. A special feature is 2,7-di-tert.-butyl substituents in the backbone which requires the modification of the original synthetic approach. In comparison to related ligands reported formerly the substitution has a considerable influence on the results (yield and % e.e.) of metal catalyzed reactions, e.g. asymmetric rhodium catalyzed hydrogenation of isophorone and the palladium catalyzed alkylation, respectively.
A process for preparing optically active aldehyde or ketone method (by machine translation)
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Paragraph 0079; 0080, (2017/07/19)
The present invention provides an asymmetric hydrogenation process for preparing optically active aldehyde or ketone of the method. The invention using transition metal catalyst and amino acid ester catalyst, so that the α, β - unsaturated aldehyde or ketone by selective asymmetric hydrogenation and the preparation of optically active aldehyde or ketone, reaction selectivity is greatly improved, the optical purity of the product can be as high as 99ee %. (by machine translation)
Method for preparing chiral 3,3,5-trimethylcyclohexanone
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Paragraph 0022; 0047, (2017/05/16)
The invention relates to a method for preparing chiral 3,3,5-trimethylcyclohexanone. The method comprises the steps of directly adding IP, a PEG stabilized nano Pd catalyst, a roasted Al2O3 carrier and S-proline into a solvent, and carrying out a reaction
