334968-79-5

Basic information

• Product Name: (2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one
• Synonyms: (2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one
• CAS NO: 334968-79-5
• Molecular Weight: 319.425
• Mol File: 334968-79-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one(334968-79-5)
• EPA Substance Registry System: (2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one(334968-79-5)

Safety Data

• Hazardous Substances Data: 334968-79-5(Hazardous Substances Data)

Upstream product

• 7319-38-2 3-butenal 
• 334968-78-4 (R)-1-(4-benzyl-2-thioxooxazolidin-3-yl)propan-1-one 

Downstream Products

• 334968-92-2 (1S,4S,5R,6R)-1,10-Bis-benzyloxy-1-[(2R,3S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-3,4-dihydro-2H-pyran-2-yl]-4-hydroxy-5-methyl-6-triethylsilanyloxy-decan-2-one 
• 334968-93-3 (2R,4S,5R,6R)-6-(4-Benzyloxy-butyl)-2-{(S)-benzyloxy-[(2R,3S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-3,4-dihydro-2H-pyran-2-yl]-methyl}-2-methoxy-5-methyl-tetrahydro-pyran-4-ol 
• 334968-81-9 (R)-4-Benzyl-3-[(2S,3R,4S,5S)-2-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4-methyl-oct-7-enoyl]-oxazolidin-2-one 
• 334968-82-0 2,2-Dimethyl-propionic acid (2R,3R,4S,5S)-2-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4-methyl-oct-7-enyl ester 
• 334968-83-1 2,2-Dimethyl-propionic acid (R)-2-benzyloxy-2-[(2R,3S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-3,4-dihydro-2H-pyran-2-yl]-ethyl ester 
• 334968-75-1 (S)-1-Benzyloxy-1-[(2R,3S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-3,4-dihydro-2H-pyran-2-yl]-propan-2-one 
• 334968-84-2 (S)-Benzyloxy-[(2R,3S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-3,4-dihydro-2H-pyran-2-yl]-acetaldehyde 

Relevant articles and documents

An aldol approach to the synthesis of the EF fragment of spongistatin 1.

A synthesis of the C29-C51 fragment of spongistatin 1, containing the E and F rings, has been completed. The approach relies on four diastereoselective aldol additions and an asymmetric glycolate alkylation to establish eight of the eleven stereogenic centers. The intact chlorodiene side chain was appended by a Lewis acid catalyzed addition of an allylstannane to an epoxy enol ether.