334976-32-8Relevant academic research and scientific papers
Total synthesis of the phytotoxic stagonolides A and B
Prabhakar, Peddikotla,Rajaram, Singanaboina,Reddy, Dorigondla Kumar,Shekar, Vanam,Venkateswarlu, Yenamandra
experimental part, p. 216 - 221 (2010/05/18)
The chemo-enzymatic and covergent synthesis of stagonolide B and the synthesis of stagonolide A, a phytotoxic 10-membered lactone have been achieved starting from d-ribose with overall yields of 25% and 8.7%, respectively. The synthesis contained simple steps in developing three centers' key intermediates, namely the enzymatic (Novozyme-435) resolution of a propargylic alcohol followed by macrolactonization and RCM.
A concise enantioselective synthesis of antimalarial febrifugine alkaloids.
Ooi,Urushibara,Esumi,Iwabuchi,Hatakeyama
, p. 953 - 955 (2007/10/03)
Reaction of (S)-2-(tert-butyldiphenylsilyloxy)-5-(mesyloxy)pentanal with hydroxylamine in allyl alcohol brought about simultaneous 1,3-dipolar cycloaddition of the resulting nitrone to allyl alcohol to give three diastereoisomeric adducts, from which (+)-febrifugine and (+)-isofebrifugine, potent antimalarial alkaloids, were synthesized.
