334976-44-2

Basic information

• Product Name: (2R,3S)-N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-[2-oxo-3-(4-oxo-4H-quinazolin-3-yl)propyl]piperidine
• Synonyms: (2R,3S)-N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-[2-oxo-3-(4-oxo-4H-quinazolin-3-yl)propyl]piperidine
• CAS NO: 334976-44-2
• Molecular Weight: 639.867
• Mol File: 334976-44-2.mol

Chemical Properties

• CAS DataBase Reference: (2R,3S)-N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-[2-oxo-3-(4-oxo-4H-quinazolin-3-yl)propyl]piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-[2-oxo-3-(4-oxo-4H-quinazolin-3-yl)propyl]piperidine(334976-44-2)
• EPA Substance Registry System: (2R,3S)-N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-[2-oxo-3-(4-oxo-4H-quinazolin-3-yl)propyl]piperidine(334976-44-2)

Safety Data

• Hazardous Substances Data: 334976-44-2(Hazardous Substances Data)

Upstream product

• 334976-41-9 N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-(2,3-dihydroxypropyl)piperidine 
• 334976-42-0 N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-[(oxiranyl)methyl]piperidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 491-36-1 4-Hydroxyquinazoline 
• 334976-43-1 N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-[2-hydroxy-3-(4-oxo-4H-quinazolin-3-yl)propyl]piperidine 

Relevant articles and documents

A concise enantioselective synthesis of antimalarial febrifugine alkaloids.

Reaction of (S)-2-(tert-butyldiphenylsilyloxy)-5-(mesyloxy)pentanal with hydroxylamine in allyl alcohol brought about simultaneous 1,3-dipolar cycloaddition of the resulting nitrone to allyl alcohol to give three diastereoisomeric adducts, from which (+)-febrifugine and (+)-isofebrifugine, potent antimalarial alkaloids, were synthesized.