334976-41-9Relevant academic research and scientific papers
A concise enantioselective synthesis of antimalarial febrifugine alkaloids.
Ooi,Urushibara,Esumi,Iwabuchi,Hatakeyama
, p. 953 - 955 (2001)
Reaction of (S)-2-(tert-butyldiphenylsilyloxy)-5-(mesyloxy)pentanal with hydroxylamine in allyl alcohol brought about simultaneous 1,3-dipolar cycloaddition of the resulting nitrone to allyl alcohol to give three diastereoisomeric adducts, from which (+)-febrifugine and (+)-isofebrifugine, potent antimalarial alkaloids, were synthesized.
