334976-45-3Relevant academic research and scientific papers
BF3·Et2O catalyzed diastereoselective nucleophilic reactions of 3-silyloxypiperidine N,O-acetal with silyl enol ether and application to the asymmetric synthesis of (+)-febrifugine
Liu, Ru-Cheng,Huang, Wei,Ma, Jing-Yi,Wei, Bang-Guo,Lin, Guo-Qiang
scheme or table, p. 4046 - 4049 (2009/10/11)
The asymmetric BF3·Et2O catalyzed nucleophilic reactions of 3-silyloxypiperidine N,O-acetal 10 with silyl enol ethers derived from ketones are described. (+)-Febrifugine 1, an antimalarial alkaloid, was successfully synthesized based
A concise enantioselective synthesis of antimalarial febrifugine alkaloids.
Ooi,Urushibara,Esumi,Iwabuchi,Hatakeyama
, p. 953 - 955 (2007/10/03)
Reaction of (S)-2-(tert-butyldiphenylsilyloxy)-5-(mesyloxy)pentanal with hydroxylamine in allyl alcohol brought about simultaneous 1,3-dipolar cycloaddition of the resulting nitrone to allyl alcohol to give three diastereoisomeric adducts, from which (+)-febrifugine and (+)-isofebrifugine, potent antimalarial alkaloids, were synthesized.
