334981-11-2

Usage

Uses

Almotriptan intermediate

InChI:InChI=1/C11H17N3O2S.ClH/c12-13-11-5-3-10(4-6-11)9-17(15,16)14-7-1-2-8-14;/h3-6,13H,1-2,7-9,12H2;1H

Upstream product

• 1112206-13-9 1-(4-amino-benzenemethanesulfonyl)pyrrolidine hydrochloride 
• 334981-10-1 4-((pyrrolidin-1-ylsulfonyl)methyl)aniline 

Downstream Products

• 1364283-62-4 C₂₂H₂₂F₃N₃O₂S 
• 1364283-57-7 C₂₁H₂₀F₃N₃O₂S 
• 1364283-51-1 3-methyl-1-(4-((pyrrolidin-1-ylsulfonyl)methyl)phenyl)-5-(thiophen-2-yl)-1H-pyrazole 
• 1020765-97-2 d2-4-[2-[4-(dimethylamino)butylidene]hydrazinyl]-benzylsulfonylpyrrolidine 

Relevant academic research and scientific papers

Synthesis of n-methyl benzenemethane sulfonamide substituted carbazoles and pyrazoles

Cyclization of 1-(4-hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride (2) with cyclohexanone (3)/N-methyl-4-piperidone (5) afforded the corresponding N-methyl-1-(2,3,4,9-tetrahydro-1H-carbazol-6-yl)methanesulfonamide (4) and N-methyl-1-(2-methyl- 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl) methane sulfonamide (6). Condensation of compound 2 with substituted aryl β-diketones gave the novel N-methyl-1-[4-(3-methyl-5-phenyl-1H-pyrazol-1- yl)phenyl]methanesulfonamide (8). All the synthesized compounds were characterized by their FT-IR, 1H NMR and mass spectral data.

NOVEL PROCESS

The present invention relates to a novel process for the preparation of almotriptan and pharmaceutically acceptable salts thereof, which affords product conveniently and efficiently with commercially acceptable yields and purity. The present invention also relates to a novel synthetic intermediate used in the process.

PREPARATION AND UTILITY OF SUBSTITUTED INDOLES

Disclosed herein are substituted indoles of Formula I, processes of preparation there of, pharmaceutical compositions thereof, and methods of their use there of.

CONVERSION OF AROMATIC DIAZONIUM SALT TO ARYL HYDRAZINE

The present invention relates to the preparation of aryl hydrazines and their salts by treating aryl diazonium salts with triphenyl phosphine followed by hydrolysis of the resulting triphenyl-aryl hydrazyl phosphonium salt to get aryl hydrazine or its sal

Synthesis of 5-(sulfamoylmethyl)indoles

The synthesis of 5-(sulfamoylmethyl)indoles bearing a two-carbon chain at C-3 (aminoethyl, acetate, hydroxyethyl, ethyl) either by the Grandberg modification of the Fischer indolization or by intramolecular Heck reaction of suitable o-halotrifluoroacetanilides is reported.