3350-74-1

Upstream product

• 201230-82-2 carbon monoxide 
• 109-75-1 but-3-enenitrile 
• 4786-20-3 crotononitrile 

Downstream Products

• 112023-01-5 N-formyl-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-(R)-α-amino-5-cyano-pentanoic acid-N'-tert-butyl-amide 
• 112023-01-5 N-formyl-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-(S)-α-amino-5-cyano-pentanoic acid-N'-tert-butyl-amide 
• 118863-56-2 6-Benzenesulfonyl-5-hydroxy-hexanenitrile 
• 138942-40-2 6-(phenylthio)hex-5-enenitrile 
• 462-94-2 1,5-diaminopentane 
• 544-13-8 Glutaronitrile 
• 112139-59-0 O-benzyl-N-(4-cyanobutyl)-hydroxylamine 
• 119825-45-5 (R)-2-Amino-5-cyano-pentanoic acid phenylamide; hydrochloride 
• 7620-28-2 D-2-aminoadipic acid 
• 690660-95-8 1-(2-amino-6-ethyl-cyclohex-1-enyl)-ethanone 
• 690660-83-4 (E)-7-Oxo-oct-5-enenitrile 
• 190522-50-0 7-oxo-7-phenylhept-5-enenitrile 
• 112023-01-5 2,2-Dimethyl-propionic acid (2R,3R,4S,5R,6R)-2-[((R)-4-cyano-1-phenylcarbamoyl-butyl)-formyl-amino]-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-3-yl ester 
• 112023-01-5 2,2-Dimethyl-propionic acid (2R,3R,4S,5R,6R)-2-[((S)-4-cyano-1-phenylcarbamoyl-butyl)-formyl-amino]-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-3-yl ester 

Relevant academic research and scientific papers

New tetraphosphorus ligands for highly linear selective hydroformylation of allyl and vinyl derivatives

New tetraphosphorus ligands have been developed and applied in the rhodium-catalyzed regioselective hydroformylation of a variety of functionalized allyl and vinyl derivatives. Remarkably high linear selectivity was obtained by these tetraphosphorus ligands. The ligand that bears strong electron-withdrawing 2,4-difluorophenyl groups is the most effective one in affording linear aldehydes. The Rh/tetraphosphorus ligand catalyst is highly effective to produce linear aldehydes from functionalized allyl derivatives with heteroatoms or aromatic groups directly adjacent to the allyl group. For vinyl derivatives, the ligand is highly linear selective for acrylic derivatives, styrene, vinyl pyridine, and vinyl phthalimide. Linear to branch ratios of 26:1 and 10:1 were obtained for the hydroformylation of styrene and allyl cyanide, respectively. New tetraphosphorus ligands have been developed and applied in the rhodium-catalyzed regioselective hydroformylation of a variety of allyl and vinyl olefins (see scheme). Remarkably high linear selectivities were obtained by these ligands. Linear-to-branch ratios of 26:1 and 10:1 were obtained for the hydroformylation of styrene and allyl cyanide, respectively. Copyright

Rhodium-Catalysed Asymmetric Hydroformylation of Unsaturated Nitriles

Asymmetric hydroformylation of crotononitrile (1) and ally cyanide (2) was probed with the view to develop a synthesis for (R)-4-amino-2-methyl-butan-1-ol. Hydroformylation of 1 under a variety of conditions mainly led to hydrogenated product. Hydroformylation of 2 with Rh/tris(2,4-di-tert-butylphenyl) phosphite gave good selectivity to the formylated nitrile with an n/iso of 77:23. Asymmetric hydroformylation of 2 could be accomplished in 66% ee using Rh/(R,S)-BINAPHOS.