335059-71-7

Basic information

• Product Name: 1H-Pyrrole-2-carboxylicacid,4-amino-1-methyl-,1,1-dimethylethylester(9CI)
• Synonyms: 1H-Pyrrole-2-carboxylicacid,4-amino-1-methyl-,1,1-dimethylethylester(9CI);1H-Pyrrole-2-carboxylicacid,4- amino-1-methyl-,1,1- dimethylethylester
• CAS NO: 335059-71-7
• Molecular Formula: C₁₀H₁₆N₂O₂
• Molecular Weight: 196.25
• Product Categories: AMINOACID
• Mol File: 335059-71-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrole-2-carboxylicacid,4-amino-1-methyl-,1,1-dimethylethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxylicacid,4-amino-1-methyl-,1,1-dimethylethylester(9CI)(335059-71-7)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxylicacid,4-amino-1-methyl-,1,1-dimethylethylester(9CI)(335059-71-7)

Safety Data

• Hazardous Substances Data: 335059-71-7(Hazardous Substances Data)

Usage

Common uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Potential properties

Anti-inflammatory and analgesic

Value

Valuable ingredient in the development of new medications for various health conditions

Additional uses

Organic synthesis and building block for the production of other complex chemical compounds

Applications

Wide range in the field of drug development and organic chemistry

Upstream product

• 96-54-8 N-Methylpyrrole 
• 21898-65-7 1-methyl-2-trichloroacetyl-1H-pyrrole 
• 13138-76-6 1-methyl-4-nitropyrrole-2-carboxylic acid methyl ester 
• 120122-47-6 1-methyl-4-nitro-2-trichloroacetylpyrrole 
• 13138-78-8 1-methyl-4-nitro-pyrrol-2-carboxylic acid 
• 67974-08-7 1-methyl-4-nitro-1H-pyrrole-2-carboxylic acid tert-butyl ester 

Downstream Products

• 195387-29-2 4-[(9-fluorenylmethoxycarbonyl)amino]-1-methyl-2-pyrrole carboxylic acid 
• 633302-83-7 C₆₈H₆₅Cl₂N₁₁O₁₀ 
• 633302-82-6 C₆₂H₅₉Cl₂N₉O₉ 
• 633302-77-9 4-{[4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 633302-80-4 4-{[4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carboxylic acid 
• 633302-76-8 4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 633302-79-1 4-({4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carboxylic acid 
• 633302-75-7 4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyrylamino]-1-methyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

A Bis(guanidinium)alcohol Attached to a Hairpin Polyamide: Synthesis, DNA Binding, and Plasmid Cleavage

Bis(guanidinium)alcohols have been designed to react with phosphodiester substrates in a fast transphosphorylation step, a quasi-intramolecular process taking place in contact ion pairs. Here the attachment of such compounds to Dervan-type hairpin polyami

NOVEL CYSTOBACTAMIDE DERIVATIVES

The present invention relates to novel derivatives of cystobactamides of formula (lb) and the use thereof for the treatment or prophylaxis of bacterial infections.

Fmoc solid phase synthesis of polyamides containing pyrrole and imidazole amino acids

Matrix presented Polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids are synthetic ligands that have an affinity and specificity for DNA comparable to those of many naturally occurring DNA binding proteins. A machine-assisted Fmoc solid phase synthesis of polyamides has been optimized to afford high stepwise coupling yields (>99%). Two monomer building blocks, Fmoc-Py acid and Fmoc-Im acid, were prepared in multigram scale. Cleavage by aminolysis followed by HPLC purification affords up to 200 mg quantities of polyamide with purities and yields greater than or equal to those reported using Boc chemistry. A broader set of reaction conditions will increase the number and complexity of minor groove binding polyamides which may be prepared and help ensure compatibility with many commercially available peptide synthesizers.