335063-18-8

Upstream product

• 144432-85-9 3-chloro-4-fluorophenylboronic acid 

Downstream Products

• 911497-62-6 (4-{1-[5-(3-chloro-4-fluoro-phenyl)-pyrimidin-4-yl]-piperidin-4-yl}-5-methyl-1H-imidazol-2-yl)-(4-methoxy-phenyl)-diazene 
• 335063-47-3 4-{1-[5-(3-chloro-4-fluoro-phenyl)-pyrimidin-4-yl]-piperidin-4-yl}-5-methyl-1H-imidazol-2-ylamine 

Relevant academic research and scientific papers

Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors

A series of potent inhibitors of the sodium hydrogen exchanger-1 (NHE-1) is described. Structure-activity relationships identified the 3-methyl-4-fluoro analog 9t as a highly potent (IC50 = 0.0065 μM) and selective (NHE-2/NHE-1 = 1400) non-acylguanidine NHE-1 inhibitor. Pharmacokinetic studies showed that compound 9t has an oral bioavailability of 52% and a plasma half life of 1.5 h in rats. Because of its promising potency, selectivity, and a good pharmacokinetic profile, compound 9t was selected for further studies.