33509-76-1

Upstream product

• 2942-10-1 6-chloro-1,3-benzothiazole 
• 762-04-9 phosphonic acid diethyl ester 
• 17142-83-5 6-chloro-2-ethylbenzo[d]thiazole 
• 23474-98-8 2-amino-5-chlorobenzenethiol 
• 75-07-0 acetaldehyde 
• 54531-34-9 1-(6-chloro-1H-benzothiazol-2-yl)ethanol 

Downstream Products

• 54469-68-0 [4-(6-chloro-benzothiazol-2-yl)-thiazol-2-yl]-phenyl-amine 
• 54469-69-1 [4-(6-chloro-benzothiazol-2-yl)-thiazol-2-yl]-(4-chloro-phenyl)-amine 
• 54469-70-4 [4-(6-chloro-benzothiazol-2-yl)-thiazol-2-yl]-(4-methoxy-phenyl)-amine 

Relevant academic research and scientific papers

Peroxides as "switches" of dialkyl H-phosphonate: Two mild and metal-free methods for preparation of 2-acylbenzothiazoles and dialkyl benzothiazol-2-ylphosphonates

Two mild and metal-free methods for the preparation of two kinds of important benzothiazole derivatives, 2-acylbenzothiazoles and dialkyl benzothiazol-2-ylphosphonates, respectively, were developed. The dialkyl H-phosphonate (RO)2P(O)H exists i

Compositions containing five-membered unsaturated heterocyclic structure of the α, β unsaturated ketone compound and its preparation method and application

The invention provides alpha, beta unsaturated ketone compounds containing benzo five-membered unsaturated heterocycle structures as well as a preparation method and an application and use of the compounds. The alpha, beta unsaturated ketone compounds containing the benzo five-membered unsaturated heterocycle structures have the structure of a formula (I). In addition, the invention further provides a method for preparing the compounds and a pharmaceutical composition containing the components as active components. In vitro activity tests show that the compounds provided by the invention show a remarkable inhibiting effect on tumor cells. Therefore, the invention lays a foundation for lucubrating and developing anti-tumor medicines in the future and meanwhile further provides a new technical means for treating tumor diseases.

Chloroacetate-promoted selective oxidation of heterobenzylic methylenes under copper catalysis

The efficient selective oxidation and functionalization of C-H bonds with molecular oxygen and a copper catalyst to prepare the corresponding ketones was achieved with ethyl chloroacetate as a promoter. In this transformation, various substituted N-heterocyclic compounds were well tolerated. Preliminary mechanistic investigations indicated that organic radical species were involved in the overall process. The N-heterocyclic compounds and ethyl chloroacetate work synergistically to activate C-H bonds in the methylene group, which results in the easy generation of free radical intermediates, thus leading to the corresponding ketones in good yields.