33511-76-1

Upstream product

• 106-40-1 4-bromo-aniline 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 

Downstream Products

• 1649438-38-9 diethyl 6-amino-4-(3-bromophenyl)-1-(4-bromophenyl)-5-cyano-1,4-dihydropyridine-2,3-dicarboxylate 
• 1649438-39-0 diethyl 6-amino-1-(4-chlorophenyl)-5-cyano-4-phenyl-1,4-dihydropyridine-2,3-dicarboxylate 
• 1649438-43-6 triethyl 6-amino-4-(2-bromophenyl)-1-(4-bromophenyl)-1,4-dihydropyridine-2,3,5-tricarboxylate 
• 1649438-42-5 triethyl 4-(4-acetamidophenyl)-6-amino-1-(4-bromophenyl)-1,4-dihydropyridine-2,3,5-tricarboxylate 
• 1238054-74-4 diethyl 3-(4-bromolphenyl)-6-oxo-2-phenyl-2-trifluoromethyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate 
• 1238054-70-0 diethyl 3-(4-bromophenyl)-6-(3-nitrophenyl)-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate 
• 1238054-68-6 diethyl 3-(4-bromophenyl)-2-oxo-6-(2-fluorophenyl)-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate 

Relevant academic research and scientific papers

Exploration of the Differences between Amine and Thiolate Addition to Acetylenedicarboxylates

Nucleophilic addition of thiolates to diethyl acetylenedicarboxylate in chloroform at room temperature affords solely the meso dithioaddition product, whereas the addition of amines in ethanol gives only the corresponding (Z)-enamine, as confirmed by X-ra

Introduction of a clean and promising protocol for the synthesis of β-amino-acrylates and 1,4-benzoheterocycles: An emerging innovation

A highly efficient, elegant and simple procedure with exceptionally mild conditions has been proposed for the synthesis of β-amino-acrylate derivatives and an array of biologically and pharmaceutically active benzoheterocycles. The protocol offers a valua