335117-39-0Relevant articles and documents
Synthesis and reactivity of (1S)-N-(1-phenylethyl)maleimide towards nucleophiles: An application to preparation of chiral pyrroloisothiochroman and pyrrolobenzo[d]thiepine based on π-cationic cyclization
Chihab-Eddine, Abderrahim,Dach, Adam,Jilale, Abderrahim,Decroix, Bernard
, p. 573 - 576 (2001)
Chiral pyrroloisothiochroman and pyrrolo[d]thiepine were obtained efficiently in four steps from N-alkylated maleimides via, successively, sulfurization, regioselective reduction followed by π-cationic cyclization of the N-acyliminium ion intermediates. These latter, in addition, led to conjugate enamides as a consequences of the dehydration reaction.