33514-63-5Relevant academic research and scientific papers
Dipeptide nitrile inhibitors of cathepsin K
Altmann, Eva,Aichholz, Reiner,Betschart, Claudia,Buhl, Thomas,Green, Jonathan,Lattmann, Rene,Missbach, Martin
, p. 2549 - 2554 (2007/10/03)
A series of dipeptidyl nitriles as inhibitors of cathepsin K have been explored starting from lead structure 1 (Cbz-Leu-NH-CH2-CN, IC 50 = 39 nM). Attachment of non-natural amino acid side chains in P1 and modification of the P3 subu
Total Synthesis of PHI
Moroder, L.,Goehring, W.,Thamm, P.,Wuensch, E.,Tatemoto, K.,et al.
, p. 772 - 780 (2007/10/02)
PHI has recently been isolated from porcine duodenum as a new peptide factor with VIP-like activities.Its primary structure corresponds to a linear heptacosapeptide amide characterized by a remarkable sequence homology to the other known members of the gl
