335151-04-7Relevant academic research and scientific papers
On the mechanism of a double ring-closing metathesis reaction
Wallace, Debra J.
, p. 591 - 594 (2005)
A detailed study of the steps involved in the double ring-closing metathesis reaction of 2 to 3 has been carried out. Both the selectivity and mechanism were affected by choice of catalyst. A detailed study of the steps involved in the double ring-closing metathesis reaction of 2 to 3 has been carried out. Both the selectivity and mechanism were affected by choice of catalyst.
Use of commercially available ruthenium fischer-type carbenes for ring-closing metathesis reactions: Scope and limitations of an in situ activation procedure
Wallace, Debra J.
scheme or table, p. 2277 - 2282 (2010/02/28)
An evaluation of two commercially available Fischer-type ruthenium carbenes in a range of ring-closing diene and enyne metathesis reactions has been carried out. A method to activate such catalysts for ring-closing reactions is presented.
A double ring closing metathesis reaction in the rapid, enantioselective synthesis of NK-1 receptor antagonists.
Wallace,Goodman,Kennedy,Davies,Cowden,Ashwood,Cottrell,Dolling,Reider
, p. 671 - 674 (2007/10/03)
[structure: see text]. The NK-1 receptor antagonist 1 has been prepared in seven steps from phenylglycine methyl ester. The key steps are a double ring closing metathesis reaction of tetraene 7 to prepare spirocycle 6 and a reductive Heck reaction to introduce the aryl moiety. This latter reaction discriminates the olefins of compound 6 and proceeds in a highly regio- and stereoselective manner.
