335151-08-1

Upstream product

• 111047-54-2 (S)-methyl 2-((4-methylphenyl)sulfonamido)-2-phenylacetate 
• 15028-39-4 L-2-phenylglycine methyl ester hydrochloride 
• 335150-99-7 N-(2-hydroxy-1-phenyl-2-vinyl-but-3-enyl)-4-methyl-benzenesulfonamide 
• 335151-02-5 N-allyl-N-(2-allyloxy-1-phenyl-2-vinyl-but-3-enyl)-4-methyl-benzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 335151-04-7 (5R,6S)-6-Phenyl-7-(toluene-4-sulfonyl)-1-oxa-7-aza-spiro[4.5]deca-3,9-diene 

Relevant academic research and scientific papers

On the mechanism of a double ring-closing metathesis reaction

A detailed study of the steps involved in the double ring-closing metathesis reaction of 2 to 3 has been carried out. Both the selectivity and mechanism were affected by choice of catalyst. A detailed study of the steps involved in the double ring-closing metathesis reaction of 2 to 3 has been carried out. Both the selectivity and mechanism were affected by choice of catalyst.

A double ring closing metathesis reaction in the rapid, enantioselective synthesis of NK-1 receptor antagonists.

[structure: see text]. The NK-1 receptor antagonist 1 has been prepared in seven steps from phenylglycine methyl ester. The key steps are a double ring closing metathesis reaction of tetraene 7 to prepare spirocycle 6 and a reductive Heck reaction to introduce the aryl moiety. This latter reaction discriminates the olefins of compound 6 and proceeds in a highly regio- and stereoselective manner.