335161-00-7

Upstream product

• 335160-95-7 3-(bromomethyl)-4-chloro-1-phenyl methanesulfonate 
• 335160-97-9 1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3,8-diaza-2-oxobicyclo[3.2.1]octane 
• 335160-81-1 5(S),3(S)-3-benzyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-[2-(phenylsulfonyloxy)ethyl]-2-piperazinone 
• 335160-93-5 1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane 
• 335160-79-7 5(S),3(S)-3-benzyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-hydroxyethyl)-2-piperazinone 
• 335160-77-5 5(S),3(S)-3-benzyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-oxoethyl)-2-piperazinone 
• 335160-83-3 1(S),5(S)-1-benzyl-8-tert-butoxycarbonyl-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane 
• 335160-63-9 (1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate 
• 335160-65-1 (S)-5-allyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-2-piperazinone 
• 90555-52-5 4'-chloro-3'-methylphenyl methanesulfonate 
• 59-50-7 4-Chloro-3-methylphenol 

Relevant academic research and scientific papers

3,8-Diazabicyclo[3.2.1]octan-2-one peptide mimetics: synthesis of a conformationally restricted inhibitor of farnesyltransferase.

A new synthesis of the 3,8-diazabicyclo[3.2.1]octan-2-one framework is described. Transannular enolate alkylation of piperazinone derivatives provides a flexible route to highly constrained bicyclic peptidomimetic synthons with substitution at the Calpha