335162-31-7Relevant articles and documents
Butyl 2-(4-[1.1′-biphenyl]-4-yl-1H-imidazol-2-yl)ethylcarbamate, a potent sodium channel blocker for the treatment of neuropathic pain
Liberatore, Anne-Marie,Schulz, Jocelyne,Favre-Guilmard, Christine,Pommier, Jacques,Lannoy, Jacques,Pawlowski, Emilia,Barthelemy, Marie-Anne,Huchet, Marion,Auguet, Michel,Chabrier, Pierre-Etienne,Bigg, Dennis
, p. 1746 - 1749 (2007)
A series of 4-arylimidazole carbamates was synthesized and their binding affinities to the site-2 sodium (Na+) channel were determined. SAR studies led to the identification of compound 10, a potent Na+ channel blocker which was efficacious in pain models in vivo.