33522-14-4

Basic information

• Product Name: 1-Benzo[1,3]dioxol-5-yl-cyclopropanecarbonitrile
• Synonyms: 1-Benzo[1,3]dioxol-5-yl-cyclopropanecarbonitrile;1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarbonitrile;1-(1,3-Benzodioxol-5-yl)cyclopropanecarbonitrile;1-(3,4-Methylenedioxyphenyl)cyclopropanecarbonitrile
• CAS NO: 33522-14-4
• Molecular Formula: C11H9NO2
• Molecular Weight: 187.197
• Mol File: 33522-14-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 347.046°C at 760 mmHg
• Flash Point: 146.158°C
• Appearance: /
• Density: 1.331g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Benzo[1,3]dioxol-5-yl-cyclopropanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzo[1,3]dioxol-5-yl-cyclopropanecarbonitrile(33522-14-4)
• EPA Substance Registry System: 1-Benzo[1,3]dioxol-5-yl-cyclopropanecarbonitrile(33522-14-4)

Safety Data

• Hazardous Substances Data: 33522-14-4(Hazardous Substances Data)

Usage

General Description

1-Benzo[1,3]dioxol-5-yl-cyclopropanecarbonitrile is a chemical compound with the molecular formula C11H7NO2. It is a derivative of cyclopropane with a benzo[1,3]dioxolyl group and a carbonitrile group attached. 1-Benzo[1,3]dioxol-5-yl-cyclopropanecarbonitrile is used in organic synthesis and pharmaceutical research as a building block for the development of new drugs and materials. It has potential applications in the field of medicinal chemistry due to its structural features and potential biological activities. However, its specific uses and properties may vary depending on the research and development context. As with all chemicals, proper handling and precautions should be taken to ensure safety and environmental responsibility.

InChI:InChI=1/C11H9NO2/c12-6-11(3-4-11)8-1-2-9-10(5-8)14-7-13-9/h1-2,5H,3-4,7H2

Upstream product

• 106-93-4 ethylene dibromide 
• 4439-02-5 3,4-methylenedioxyphenylacetonitrile 
• 107-04-0 1-Bromo-2-chloroethane 

Downstream Products

• 862574-89-8 1-(2H-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid 

Relevant articles and documents

Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

We herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the first time. A variety of substrates with α-quaternary carbon centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. We have also demonstrated that the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.

SUBSTITUTED UREA-OCTAHYDROINDOLS AS ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR 1 (MCH1R)

The invention relates to compounds of the general formula (I). (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, and X are as defined in the description, or pharmaceutically acceptable salts, hydrates, geometrical isomers, racemates, tautomers, optical isomers, N-oxides and prodrug forms thereof. The compounds may be used for the treatment or prophylaxis of disorders related to the MCH1R receptor and for modulation of appetite. The invention also relates to such use as well as to pharmaceutical formulations comprising a compound of formula (I).