33522-14-4

Usage

Uses

Used in Organic Synthesis:
1-Benzo[1,3]dioxol-5-yl-cyclopropanecarbonitrile is utilized as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique structural features make it a versatile component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-Benzo[1,3]dioxol-5-yl-cyclopropanecarbonitrile is employed as a building block for drug development. Its incorporation into the molecular structures of potential drugs allows for the exploration of new therapeutic agents with novel mechanisms of action and improved pharmacological properties.
Used in Medicinal Chemistry:
1-Benzo[1,3]dioxol-5-yl-cyclopropanecarbonitrile holds promise in the field of medicinal chemistry due to its structural attributes and potential biological activities. Researchers leverage its properties to design and develop new pharmaceutical agents that target specific diseases and conditions.

InChI:InChI=1/C11H9NO2/c12-6-11(3-4-11)8-1-2-9-10(5-8)14-7-13-9/h1-2,5H,3-4,7H2

Upstream product

• 106-93-4 ethylene dibromide 
• 4439-02-5 3,4-methylenedioxyphenylacetonitrile 
• 107-04-0 1-Bromo-2-chloroethane 

Downstream Products

• 862574-89-8 1-(2H-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid 

Relevant academic research and scientific papers

Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

We herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the first time. A variety of substrates with α-quaternary carbon centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. We have also demonstrated that the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.

Enantioselective C-H Functionalization-Addition Sequence Delivers Densely Substituted 3-Azabicyclo[3.1.0]hexanes

An enantioselective C-H functionalization route to perfluoroalkyl-containing 3-azabicyclo[3.1.0]hexanes is disclosed. A modular and bench-stable diazaphospholane ligand enables highly enantioselective Pd(0)-catalyzed cyclopropane C-H functionalization using trifluoroacetimidoyl chlorides as electrophilic partners. In turn, the resulting cyclic ketimine products react smoothly with a broad variety of nucleophiles in one-pot processes enabling the rapid and modular construction of heavily substituted pyrrolidines.

SUBSTITUTED UREA-OCTAHYDROINDOLS AS ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR 1 (MCH1R)

The invention relates to compounds of the general formula (I). (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, and X are as defined in the description, or pharmaceutically acceptable salts, hydrates, geometrical isomers, racemates, tautomers, optical isomers, N-oxides and prodrug forms thereof. The compounds may be used for the treatment or prophylaxis of disorders related to the MCH1R receptor and for modulation of appetite. The invention also relates to such use as well as to pharmaceutical formulations comprising a compound of formula (I).