335259-27-3

Usage

Uses

Used in Pharmaceutical Industry:
[1,1'-Biphenyl]-3,4-diamine, 4'-fluorois used as a building block for the development of new pharmaceutical compounds. The presence of the fluorine substitution enhances the bioavailability and potency of drugs, making it a valuable component in medicinal chemistry.
Used in Materials Science:
[1,1'-Biphenyl]-3,4-diamine, 4'-fluorois used as a component in the development of advanced materials. Its unique biphenyl structure and fluorine substitution contribute to the creation of materials with specific properties tailored for various applications.
Used in Organic Synthesis:
[1,1'-Biphenyl]-3,4-diamine, 4'-fluorois used as a key intermediate in the synthesis of complex organic compounds. Its structural features allow for further functionalization and modification, enabling the development of a wide range of organic molecules for various purposes.

Upstream product

• 20691-72-9 4-iodo-2-nitroaniline 
• 5228-61-5 5-bromo-2-nitroaniline 

Downstream Products

• 335259-26-2 8-(4-Fluoro-phenyl)-4-(2-hydroxy-phenyl)-1,3-dihydro-benzo [b][1,4]diazepin-2-one 
• 1179813-46-7 7-(5-(4-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-N-hydroxyheptanamide 
• 1449690-87-2 C₂₁H₂₃FN₂O₂ 
• 640271-64-3 C₂₆H₂₁FN₂O₂ 
• 1078728-23-0 C₂₆H₂₃FN₂O₃ 
• 694532-06-4 2-[6-(4-fluorophenyl)-3-oxo-3.4-dihydroquinoxalin-2-yl]-1H-indole-5-carbonitrile 
• 694532-05-3 2-[7-(4-fluorophenyl)-3-oxo-3.4-dihydroquinoxalin-2-yl]-1H-indole-5-carbonitrile 

Relevant academic research and scientific papers

Synthesis of Structurally Diverse Benzotriazoles via Rapid Diazotization and Intramolecular Cyclization of 1,2-Aryldiamines

An operationally simple method has been developed for the preparation of N-unsubstituted benzotriazoles by diazotization and intramolecular cyclization of a wide range of 1,2-aryldiamines under mild conditions, using a polymer-supported nitrite reagent and p-tosic acid. The functional group tolerance of this approach was further demonstrated with effective activation and cyclization of N-alkyl, -aryl, and -acyl ortho-aminoanilines leading to the synthesis of N1-substituted benzotriazoles. The synthetic utility of this one-pot heterocyclization process was exemplified with the preparation of a number of biologically and medicinally important benzotriazole scaffolds, including an α-amino acid analogue.

Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents

A series of benzimidazole based HDAC inhibitors have been rationally designed, synthesized and screened. The SAR of this new chemotype is described. The lead compound, 11e, showed strong activity in several cellular assays and demonstrated in vivo efficacy in mouse xenograft pancreatic cancer models.