33526-40-8Relevant academic research and scientific papers
Preparation method of metandienone
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Paragraph 0036-0056, (2019/03/06)
The invention provides a preparation method of metandienone. The method comprises the following steps: adopting 1,4-androstadienedione, namely IDD, as a raw material; introducing alpha-CH3 and beta-OHto 17th site in the presence of methyl-Grignard-reagent, an organic solvent and acid to obtain the metandienone. Compared with a traditional method taking diosgenin as a raw material, a method for preparing the metandienone by taking the IDD as the raw material, disclosed by the invention, has the advantages that sources of raw materials are wide, a process is economic and environmentally-friendly, and the production cost is greatly reduced; besides, the method disclosed by the invention, compared with the traditions method, has the characteristics of short synthesis route, simple and environmentally-friendly process, high product yield and good quality; calculated by the current price of the raw materials, the cost of the raw materials for production is reduced by 40 to 45 percent.
Studies on anabolic steroids. 9. Tertiary sulfates of anabolic 17α-methyl steroids: synthesis and rearrangement
Bi, Honggang,Masse, Robert,Just, George
, p. 306 - 312 (2007/10/02)
A simple and convenient method has been developed to prepare sulfates of anabolic 17β-hydroxy-17α-methyl steroids.The sulfates of methandienone, 17α-methyltestosterone, mestanolone, oxandrolone, and stanozolol were prepared.Different A-ring functions were not affected under the sulfation condition.The buffered hydrolyses of these sulfates provided the 17-epimers of the original steroids and 17,17-dimethyl-18-nor-13(14)-ene steroids, presumably via the 17-carbocations. Keywords: steroids, tertiary sulfates; 17α-methyl steroids; 17β-methyl steroids; 17,17-dimethyl-18-norandrost-13(14)-enes; NMR
