33526-40-8Relevant articles and documents
Preparation method of metandienone
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Paragraph 0036-0056, (2019/03/06)
The invention provides a preparation method of metandienone. The method comprises the following steps: adopting 1,4-androstadienedione, namely IDD, as a raw material; introducing alpha-CH3 and beta-OHto 17th site in the presence of methyl-Grignard-reagent, an organic solvent and acid to obtain the metandienone. Compared with a traditional method taking diosgenin as a raw material, a method for preparing the metandienone by taking the IDD as the raw material, disclosed by the invention, has the advantages that sources of raw materials are wide, a process is economic and environmentally-friendly, and the production cost is greatly reduced; besides, the method disclosed by the invention, compared with the traditions method, has the characteristics of short synthesis route, simple and environmentally-friendly process, high product yield and good quality; calculated by the current price of the raw materials, the cost of the raw materials for production is reduced by 40 to 45 percent.