335265-99-1

Basic information

• Product Name: 1(2H)-Pyridinecarboxylic acid, 2-ethenyl-3,4-dihydro-4-oxo-, phenylmethyl ester
• CAS NO: 335265-99-1
• Molecular Formula: C15H15NO3
• Molecular Weight: 257.289
• Mol File: 335265-99-1.mol

Chemical Properties

• CAS DataBase Reference: 1(2H)-Pyridinecarboxylic acid, 2-ethenyl-3,4-dihydro-4-oxo-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Pyridinecarboxylic acid, 2-ethenyl-3,4-dihydro-4-oxo-, phenylmethyl ester(335265-99-1)
• EPA Substance Registry System: 1(2H)-Pyridinecarboxylic acid, 2-ethenyl-3,4-dihydro-4-oxo-, phenylmethyl ester(335265-99-1)

Safety Data

• Hazardous Substances Data: 335265-99-1(Hazardous Substances Data)

Upstream product

• 620-08-6 4-methoxypyridine 
• 1826-67-1 vinyl magnesium bromide 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 591248-53-2 1-((benzyloxy)carbonyl)-2,5-divinyl-2,3-dihydro-4-pyridone 
• 591248-54-3 [1-(2-naphthalen-2-yl-2-oxo-ethyl)-allyl]-carbamic acid benzyl ester 
• 591248-55-4 (1-formyl-3-naphthalen-2-yl-3-oxopropyl)carbamic acid benzyl ester 
• 860456-37-7 5-iodo-1-((benzyloxy)carbonyl)-2-vinyl-2,3-dihydro-4-pyridone 
• 335266-02-9 4-oxo-2-vinyl-pyridine-1-carboxylic acid benzyl ester 

Relevant articles and documents

CYCLIC AMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

A compound of formula (I) wherein R represents a radical selected from i) ii) iii) iv) where the substituents R1, R2, R3, R4, R4, R7 and the indices m, n and p are as defined in the description; or pharmaceutically acceptable salts and solvates

Synthesis of Bridged Azabicyclic Structures via Ring-Closing Olefin Metathesis

A new strategy for the facile synthesis of azabicyclo[m.n.1]alkenes (m = 3-5; n = 3, 2) has been developed that involves the ring-closing metathesis (RCM) reaction of cis-2,6-dialkenyl-N-acyl piperidine derivatives. The requisite 2,6-dialkenylpiperidines may be readily prepared in six steps starting from glutarimide (11) or three steps from 4-methoxypyridine (25). In one example that establishes the practical utility of the procedure, the functionalized 8-azabicyclo [3.2.1] octane 32, which is a potential intermediate for the syntheses of various tropane alkaloids, was prepared. Additionally, a new route for the construction of the bridged tetrahydro-β-carboline ring system 5 has been developed that features the ring-closing metathesis of the enyne 45 to construct the bridging ring in 46. This concise route to 46 also features a potentially general and useful procedure for the one-step preparation of a terminal alkyne from an ester function. Selective oxidation of the vinyl group in 46 afforded the unsaturated aldehyde 47, which may serve as a useful intermediate in syntheses of several Sarpagine alkaloids.

A ring-closing olefin metathesis approach to bridged azabicyclic structures

A facile and general entry to functionalized bridged bicyclic nitrogen heterocycles has been developed that involves the ring-closing metathesis (RCM) of cis-2,6-dialkenyl-N-acyl piperidines that were readily prepared from glutarimide or 4-methoxypyridine