335349-60-5

Upstream product

• 335349-57-0 2-nitro-4-iodo-5-chloroaniline 
• 75-65-0 tert-butyl alcohol 
• 503-38-8 trichloromethyl chloroformate 

Downstream Products

• 473547-14-7 (5-dimethylamino-4-iodo-2-nitro-phenyl)-carbamic acid tert.-butyl ester 
• 335349-81-0 (4-iodo-5-morpholin-4-yl-2-nitro-phenyl)-carbamic acid tert.-butyl ester 
• 335349-85-4 [5-(4-hydroxy-piperidin-1-yl)-4-iodo-2-nitro-phenyl]-carbamic acid tert.-butyl ester 
• 335349-90-1 [5-(2-hydroxy-ethylamino)-4-iodo-2-nitro-phenyl]-carbamic acid tert.-butyl ester 
• 335349-84-3 {5-[(2-hydroxy-ethyl)-methyl-amino]-4-iodo-2-nitro-phenyl}-carbamic acid tert.-butyl ester 
• 335349-91-2 [5-((R)-3-Hydroxy-pyrrolidin-1-yl)-4-iodo-2-nitro-phenyl]-carbamic acid tert.-butyl ester 
• 335349-92-3 [5-(2-Dimethylamino-ethylsulfanyl)-4-iodo-2-nitro-phenyl]-carbamic acid tert.-butyl ester 
• 335349-93-4 (5-tert.-butoxycarbonylamino-2-iodo-4-nitro-phenylsulfanyl)-acetic acid methyl ester 
• 1068660-88-7 C₁₉H₂₀ClIN₂O₅ 
• 1068660-87-6 C₁₃H₁₆ClIN₂O₄ 
• 1068660-89-8 C₁₈H₁₇Cl₂IN₂O₄ 
• 1068660-90-1 C₁₄H₂₀IN₃O₄ 
• 335349-89-8 C₁₅H₂₀IN₃O₄ 
• 335349-86-5 {5-[4-(2-hydroxy-ethoxy)-piperidin-1-yl]-4-iodo-2-nitro-phenyl}-carbamic acid tert.-butyl ester 

Relevant academic research and scientific papers

A highly efficient synthesis route for the rapid generation of 1,2,5,6-tetrasubstituted benzimidazoles

Herein we describe the facile generation of novel benzimidazoles starting from 5-chloro-4-iodo-2-nitroaniline. A synthesis protocol was established which allows the parallel synthesis of compound arrays as well as the rapid generation of single representa

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1

A series of 1,3-dihydrobenzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Attachment of an 8-(2-aryl)-ethynyl-moiety produced compounds inhibiting the binding of [3H]-LY354740 to rat mGluR2 with low n

Dihydro-benzo [b][1,4]diazepin-2-one derivatives

This invention is a dihydro-benzo[b][1,4]diazepin-2-one derivative of the formula wherein R1, R2, R3, X and Y are as defined in the specification. The invention includes pharmaceutical compositions containing these compounds, a process for their preparation, their use in preparation of pharmaceutical compositions and administration of an effective amount of the compounds for the treatment or prevention of acute and/or chronic neurological disorders to a patient in need of such treatment.

Glutamate receptor antagonists

The present invention relates to compounds of with a base structure of formula 1 The compounds of formula I are shown to have activity as metabotropic glutamate receptor antagonists.