335353-37-2Relevant academic research and scientific papers
Synthesis of (E,Z)-5-bromo-1,1-dimethoxy-5-trimethylsilyl-4-pentene, an upper chain allenic prostaglandin building block
Guzman-Duran, Antonio,Guzman, Esther,Pannell, Keith H.,Lloyd, Winston D.
, p. 3271 - 3283 (2003)
This work explores the synthetic route to allenic prostaglandins. In a search for more efficient and reliable methods for the introduction of the allene moiety into the side chains of prostaglandins, the synthons, the (E) and (Z) isomers of 1-bromo-5,5-dimethoxy-1-trimethylsilyl-1-pentene (13a) and (13b), have been prepared and converted to R,S-1,1-dimethoxy-6-phenyl-4,5-hexadiene (16), a prostaglandin analog.
