33537-99-4

Basic information

• Product Name: 6-Chloro-1,2,3,4-tetrahydroisoquinoline
• Synonyms: C90101;Isoquinoline, 6-chloro-1,2,3,4-tetrahydro-;6-Chloro-1,2,3,4-tetraisoquinoline;6-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
• CAS NO: 33537-99-4
• Molecular Formula: C₉H₁₀ClN
• Molecular Weight: 167.64
• EINECS: -0
• Mol File: 33537-99-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 189-191 °C(Solv: ethanol (64-17-5))
• Boiling Point: 267.686 °C at 760 mmHg
• Flash Point: 115.693 °C
• Appearance: /
• Density: 1.162 g/cm³
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.25±0.20(Predicted)
• CAS DataBase Reference: 6-Chloro-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-1,2,3,4-tetrahydroisoquinoline(33537-99-4)
• EPA Substance Registry System: 6-Chloro-1,2,3,4-tetrahydroisoquinoline(33537-99-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 33537-99-4(Hazardous Substances Data)

Usage

Uses

6-Chloro-1,2,3,4-tetrahydroisoquinoline

InChI:InChI=1/C9H10ClN/c10-9-2-1-7-3-4-11-6-8(7)5-9/h1-2,5,11H,3-4,6H2

Upstream product

• 587-04-2 m-Chlorobenzaldehyde 
• 99839-77-7 N-(3-chlorophenethyl)formamide 
• 1421697-68-8 8-chloro-6,10b-dihydro-5H-oxazolo[2,3-a]isoquinoline-2,3-dione 
• 22246-02-2 6-chloro-3,4-dihydro-1(2H)-isoquinolinone 
• 108-95-2 phenol 
• 111874-98-7 3-[2-(3-Chloro-phenyl)-ethylsulfamoyl]-propionic acid methyl ester 
• 1529-41-5 3-chloro-benzeneacetonitrile 
• 54879-73-1 [1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-(2,2-dimethoxy-ethyl)-amine 
• 104-88-1 4-chlorobenzaldehyde 
• 13078-79-0 2-(3-chlorophenyl)ethylamine 
• 26011-71-2 N-<2-(3-chlorophenyl)ethyl>acetamide 
• 3156-35-2 1-Chloro-3-((Z)-2-nitro-vinyl)-benzene 
• 111875-08-2 N-(2-methoxycarbonylethylsulfonyl)-6-chloro-1,2,3,4-tetrahydroisoquinoline 
• 62882-02-4 6-chloroisoquinoline 

Downstream Products

• 1552304-53-6 6-chloro-2-(2-chlorobenzyl)-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Easy Access to 2,4-Disubstituted Cyclopentenones by a Gold(III)-Catalyzed A3-Coupling/Cyclization Cascade

An efficient and convenient synthesis of 2,4-disubstituted cyclopentenones has been achieved through a Au(III)-catalyzed isomerization-A3-coupling/cyclization cascade. A possible mechanism involving an initial Au(III)-catalyzed isomerization, A3-type coupling, and cyclization via an enol intermediate is postulated.

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An efficient metal-free, (NH4)2S2O8 mediated intramolecular oxidative cyclization for the construction of polycyclic heterocycles was disclosed. A series of polycyclic quinazolinone derivatives with good functional group tolerance were obtained in high yields. The natural products tryptanthrin and rutaecarpine, as well as their derivatives, were easily synthesized by this strategy. A preliminary mechanism study suggested the carbon-centered radical was involved in the catalytic cycle.

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