335381-92-5

Upstream product

• 100-46-9 benzylamine 
• 335382-53-1 (2S,3S,4R)-4-[[(cyanoimino)phenoxymethyl]amino]-6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]-5,5-dimethyldioxan-2-yl)-2H-1-benzopyran 
• 335382-02-0 (2S)-2-methyl-2-dimethoxymethyl-6-nitro-2H-1-benzopyran 
• 146821-83-2 3,4-dihydro-2-dimethoxymethyl-4-hydroxy-2-methyl-6-nitro-2H-1-benzopyran 
• 380912-53-8 (2S,4S)-3,4-dihydro-2-dimethoxymethyl-4-hydroxy-2-methyl-6-nitro-2H-1-benzopyran 
• 335382-32-6 (2S)-2-methyl-2-([1,3]-5,5-dimethyldioxan-2-yl)-6-nitro-2H-1-benzopyran 
• 335382-33-7 (2S,3S,4S)-2-methyl-2-([1,3]-5,5-dimethyldioxan-2-yl)-6-nitro-3,4-epoxy-3,4-dihydro-2H-1-benzopyran 
• 380912-51-6 (2S,4S)-3,4-dihydro-2-dimethoxymethyl-4-(R-(-)-α-methoxyphenylacetoxy)-2-methyl-6-nitro-2H-1-benzopyran 
• 335382-34-8 (2S,3S,4R)-2-methyl-2-([1,3]-5,5-dimethyldioxan-2-yl)-6-nitro-3-hydroxy-4-amino-3,4-dihydro-2H-1-benzopyran 

Relevant academic research and scientific papers

BENZOPYRANYL GUANIDINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention relates to novel benzopyranyl guanidine derivatives of formula (1), wherein R1, R2, R3, R4, R5, R6, n and * are each defined in specification, process for preparation thereof and pharmaceutical use of the benzopyranyl guanidine deriv

A novel anti-ischemic ATP-sensitive potassium channel (KATP) opener without vasorelaxation: N-(6-aminobenzopyranyl)-N′-benzyl- N″-cyanoguanidine analogue

This paper describes the design, synthesis, and biological evaluation of a novel anti-ischemic compound, (2S,3S,4R)-N-(6-amino-3,4-dihydro-2-dimethoxymethyl-3-h ydroxy-2-methyl-2H-benzopyranyl)-N′-benzyl-N″-cyanoguanidine (33), and the structure-activity