663601-35-2Relevant academic research and scientific papers
Conformationally Constrained Analogues of Diacylglycerol. 20. The Search for an Elusive Binding Site on Protein Kinase C through Relocation of the Carbonyl Pharmacophore Along the sn-1 Side Chain of 1,2-Diacylglycerol Lactones
Tamamura, Hirokazu,Sigano, Dina M.,Lewin, Nancy E.,Blumberg, Peter M.,Marquez, Victor E.
, p. 644 - 655 (2007/10/03)
Previous studies with 1,2-diacylglycerol (DAG) lactones, which behave as high-affinity ligands for protein kinase C (PK-C), have established the importance of maintaining intact the pharmacophore triad of two carbonyl moieties (sn-1 and sn-2) and the prim
