335417-26-0Relevant articles and documents
Neuraminidase inhibitors
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, (2008/06/13)
The present invention provides compounds of formula Ia and Ib or a pharmaceutically acceptable salt, prodrug, or ester thereof, useful in the inhibition of neuraminidase enzymes from disease-causing microorganisms, especially influenza neuraminidase, phar
Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm.
Hanessian, Stephen,Wang, Jianchio,Montgomery, Debra,Stoll, Vincent,Stewart, Kent D,Kati, Warren,Maring, Clarence,Kempf, Dale,Hutchins, Charles,Laver, W Graeme
, p. 3425 - 3429 (2007/10/03)
Structure-based design has led to the synthesis of a novel analogue of GS-4071, an influenza neuraminidase inhibitor, in which the basic amino group has been replaced by a hydrophobic vinyl group. An X-ray co-crystal structure of the new inhibitor (K(i)=4