33543-18-9

Basic information

• Product Name: Cyclohexanone, 2,5,5-trimethyl-
• CAS NO: 33543-18-9
• Molecular Formula: C9H16O
• Molecular Weight: 140.225
• Mol File: 33543-18-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 2,5,5-trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 2,5,5-trimethyl-(33543-18-9)
• EPA Substance Registry System: Cyclohexanone, 2,5,5-trimethyl-(33543-18-9)

Safety Data

• Hazardous Substances Data: 33543-18-9(Hazardous Substances Data)

Upstream product

• 39776-34-6 3-chloro-2,5,5-trimethyl-cyclohex-2-enone 
• 42747-41-1 trimethyl-2,5,5-cyclohexene-2-one-1 
• 563-20-2 5,5-dimethylcyclohexane-1,2-dione 
• 74-88-4 methyl iodide 
• 2979-19-3 3,3-dimethylcyclohexanone 
• 93499-96-8 (E)-2-((dimethylamino)methylene)-5,5-dimethylcyclohexanone 
• 60934-84-1 (1,4,4-trimethylcyclohex-2-en-1-ol) 
• 1073-13-8 4,4-dimethylcyclohexenone 
• 23438-77-9 3,6,6-trimethyl-2-cyclohexen-1-one 
• 59270-16-5 2,5,5-Trimethylcyclohex-2-en-1-ol 
• 1125-11-7 methyldimedone 

Downstream Products

• 35482-84-9 4a,7,7-Trimethyl-2-oxo-2,3,4,4a,5,6,7,8-octahydro-naphthalene-1-carboxylic acid ethyl ester 
• 1259014-71-5 methyl 3-(1-hydroxy-2,2,5-trimethylcyclohexyl)propiolate 
• 15189-14-7 2,2,5,5-tetramethylcyclohexanone 
• 852247-48-4 ((S)-1-Phenyl-ethyl)-(2,5,5-trimethyl-cyclohex-1-enyl)-amine 
• 16778-23-7 2,5,5-Trimethyl-2-allyl-cyclohexanon 

Relevant articles and documents

Selective α-Methylation of Ketones

The convenient and scalable preparative approach for the two-step α-methylation of ketones is described. The optimized protocols for regioselective preparation of enaminones with further diastereoselective and functional groups tolerant hydrogenation to α-methylketones are developed. The scope and limitations of the proposed methodology are discussed. The advantages compared to known procedures are demonstrated. The unexpected role of acetone in the hydrogenation is suggested. The evaluation of the method for both early building block synthesis and late-stage CH-functionalization is shown. The elaborate procedures' preparability and scalability are demonstrated by the synthesis of several α-methyl ketones up to 100 g amount.

Pyrrolopyrazinyl Urea Kinase Inhibitors

The present invention relates to the use of novel pyrrolopyrazinyl urea derivatives of Formula I, wherein the variables R1, R2, R3, R4, and R5 are defined as described herein, which inhibit JAK and are useful for the treatment of auto-immune and inflammatory diseases.