33545-97-0

Basic information

• Product Name: N,N'-Di-Boc-1,4-butanediaMine
• Synonyms: N,N'-Di-Boc-1,4-butanediaMine;1,4-bis(tert-butoxycarbonylamino)butane
• CAS NO: 33545-97-0
• Molecular Formula: C₁₄H₂₈N₂O₄
• Molecular Weight: 288.38312
• EINECS: -0
• Mol File: 33545-97-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N,N'-Di-Boc-1,4-butanediaMine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-Di-Boc-1,4-butanediaMine(33545-97-0)
• EPA Substance Registry System: N,N'-Di-Boc-1,4-butanediaMine(33545-97-0)

Safety Data

• Hazardous Substances Data: 33545-97-0(Hazardous Substances Data)

Usage

General Description

N,N'-Di-Boc-1,4-butanediaMine, also known as N,N'-Di-tert-butoxycarbonyl-1,4-butanediaMine, is a chemical compound used as a reagent in organic synthesis. It is a diamine derivative with tert-butoxycarbonyl (Boc) protecting groups on both amine functionalities. These protecting groups are often used to prevent unwanted reactions during chemical synthesis and can be easily removed under mild conditions to reveal the free amines. N,N'-Di-Boc-1,4-butanediaMine is commonly used in the synthesis of peptide and pharmaceutical compounds, as well as in the preparation of a variety of other organic compounds.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 110-60-1 1,4-diaminobutane 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 

Downstream Products

• 122632-07-9 Methyl-(4-methylamino-butyl)-carbamic acid tert-butyl ester 
• 68076-36-8 1-amino-4-[(tert-butyloxycarbonyl)amino]butane 
• 16011-97-5 N,N'-dimethyl-1,4-butanediamine 

Relevant articles and documents

Flow-mediated synthesis of Boc, Fmoc, and Dd iv monoprotected diamines

A series of monoprotected aliphatic diamines (21 examples) were synthesized via continuous flow methods. The carbamates and enamines were obtained in 45-91% yields using a 0.5 mm diameter PTFE tubular flow reactor. Using readily accessible protecting group precursors, the procedure serves as an attractive alternative to existing batch-mode synthetic routes by providing direct, multigram access to N-Boc-, N-Fmoc-, and N-Ddiv-protected compounds with productivity indexes of 1.2-3.6 g/h.

Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines

A series of artemisinin-spermidine conjugates designed to utilise the upregulated polyamine transporter found in cancer cells have been prepared. These conjugates were evaluated against human promyelocytic leukaemia HL-60 cells and chloroquine-sensitive 3

Partially Protected Polyamines

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