33545-97-0

Usage

Uses

Used in Pharmaceutical Synthesis:
N,N'-Di-Boc-1,4-butanediaMine is used as a protecting agent in the synthesis of pharmaceutical compounds. The Boc protecting groups allow chemists to selectively perform reactions on specific functional groups while preventing unwanted side reactions on the amine groups. This selective protection is crucial for the successful synthesis of complex drug molecules.
Used in Peptide Synthesis:
In peptide synthesis, N,N'-Di-Boc-1,4-butanediaMine is employed as a protected diamine building block. The Boc groups ensure that the amine functionalities do not participate in unwanted reactions during the assembly of peptide chains. Once the desired peptide sequence is formed, the Boc groups can be removed to reveal the free amines, allowing for further reactions or the formation of peptide bonds.
Used in Organic Synthesis:
N,N'-Di-Boc-1,4-butanediaMine is used as a versatile reagent in the preparation of a variety of organic compounds. The Boc protecting groups enable chemists to carry out reactions on other functional groups present in the molecule while keeping the amine groups inert. This selective reactivity is valuable for the synthesis of complex organic molecules with multiple functional groups.
Used in Chemical Research:
In the field of chemical research, N,N'-Di-Boc-1,4-butanediaMine serves as a valuable tool for studying the reactivity and selectivity of amine groups in various chemical reactions. The ability to selectively protect and deprotect the amine functionalities allows researchers to gain insights into the underlying reaction mechanisms and develop new synthetic strategies.
Used in the Preparation of Chiral Compounds:
N,N'-Di-Boc-1,4-butanediaMine is also used in the synthesis of chiral compounds, where the control of stereochemistry is crucial. The Boc protecting groups can be selectively removed to generate enantiomerically pure amines, which can then be used as building blocks for the preparation of chiral pharmaceuticals and other chiral molecules.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 110-60-1 1,4-diaminobutane 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 

Downstream Products

• 16011-97-5 N,N'-dimethyl-1,4-butanediamine 
• 68076-36-8 1-amino-4-[(tert-butyloxycarbonyl)amino]butane 
• 122632-07-9 Methyl-(4-methylamino-butyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Flow-mediated synthesis of Boc, Fmoc, and Dd iv monoprotected diamines

A series of monoprotected aliphatic diamines (21 examples) were synthesized via continuous flow methods. The carbamates and enamines were obtained in 45-91% yields using a 0.5 mm diameter PTFE tubular flow reactor. Using readily accessible protecting group precursors, the procedure serves as an attractive alternative to existing batch-mode synthetic routes by providing direct, multigram access to N-Boc-, N-Fmoc-, and N-Ddiv-protected compounds with productivity indexes of 1.2-3.6 g/h.

New ianthelliformisamine derivatives as antibiotic enhancers against resistant gram-negative bacteria

A series consisting of ianthelliformisamimes A, B, and C as well as its synthetic analogues was prepared in high chemical yield, from 27 to 91%, using peptide coupling as the key step, and the compounds were evaluated for their in vitro antibiotic enhancer properties against resistant Gram-negative bacteria and clinical isolates. The mechanism of action of one of these derivatives against Pseudomonas aeruginosa when combined with doxycycline was precisely evaluated utilizing bioluminescence to measure ATP efflux and fluorescence to evaluate membrane depolarization.

Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines

A series of artemisinin-spermidine conjugates designed to utilise the upregulated polyamine transporter found in cancer cells have been prepared. These conjugates were evaluated against human promyelocytic leukaemia HL-60 cells and chloroquine-sensitive 3

Mono-protected Diamines. N-tert-Butoxycarbonyl-α,ω-alkanediamines from α,ω-Alkanediamines

We wish to report a convenient pathway to N-tert-butoxycarbonyl-α,ω-alanediamines 2a-e by treatment of the corresponding α,ω-alkanediamine with di-tert-butyl dicarbonate in dioxane as the solvent.Only small amounts of the bis-substituted N,N'-tert-butoxycarbonyl-α,ω-aldnediamines 3a-e were formed (2-9percent) which were easily removed by an aquous workup.The α,ω-alkane-aza-diamine 4 was also mono-protected (62percent yield of 5) by the same methodology.