33549-66-5

Basic information

• Product Name: 4,4-Dibromo-3-methyl-2-pyrazolin-5-one, 98+%
• Synonyms: 4,4-Dibromo-3-methyl-2-pyrazolin-5-one, 98+%;4,4-Dibromo-3-methyl-1H-pyrazol-5(4H)-one;4,4-Dibromo-3-methyl-2-pyrazolin-5-one;4,4-DibroMo-2,4-dihydro-5-Methyl-3H-pyrazol-3-one
• CAS NO: 33549-66-5
• Molecular Formula: C₄H₄Br₂N₂O
• Molecular Weight: 255.8954
• Mol File: 33549-66-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 129-132°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 2.44g/cm³
• Refractive Index: 1.71
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Very Slightly)
• PKA: 9.27±0.60(Predicted)
• CAS DataBase Reference: 4,4-Dibromo-3-methyl-2-pyrazolin-5-one, 98+%(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-Dibromo-3-methyl-2-pyrazolin-5-one, 98+%(33549-66-5)
• EPA Substance Registry System: 4,4-Dibromo-3-methyl-2-pyrazolin-5-one, 98+%(33549-66-5)

Safety Data

• Hazardous Substances Data: 33549-66-5(Hazardous Substances Data)

Usage

Uses

4,4-Dibromo-2,4-dihydro-5-methyl-3H-pyrazol-3-one is used in the preparation of antimoebic compounds such as thiosemicarbazide derivatives. Also used in the preparation of triazine molecules displaying antifungal activity.

InChI:InChI=1/C4H4Br2N2O/c1-2-4(5,6)3(9)8-7-2/h1H3,(H,8,9)

Upstream product

• 4344-87-0 1,2-dihydro-5-methyl-3H-pyrazol-3-one 
• 3206-39-1 3-methyl-2-pyrazoline-5-one 
• 108-26-9 3-methyl-2-pyrazoline-5-one 

Downstream Products

• 79746-51-3 9,10-dioxa-anti-(methyl,methyl)(methy,bromo)bimane 
• 74235-59-9 2,6-dibromo-3,7-dimethyl-1H,5H pyrazolo<1,2-a>pyrazole-1,5-dione 
• 68654-22-8 9,10-dioxa-syn-(methyl,methyl)bimane 
• 68654-23-9 3,4,7,8-tetramethyl-1,5-diazabicyclo<3.3.0>octa-3,7-diene-2,6-dione 
• 1142096-13-6 4-bromo-3,5-d2-2,6-bis(methyl-d3)phenol 
• 590-93-2 2-Butynoic acid 
• 436085-95-9 3,7-dimethylpyrazolo[3,4-e][4,1,2]oxadiazine 

Relevant articles and documents

Synthetic method of alpha-position dibromination of alpha-heterocyclic carbonyl compound

The invention discloses a synthetic method of alpha-position dibromination of an alpha-heterocyclic carbonyl compound, and belongs to the technical field of organic synthesis, and the method comprisesthe following steps: by taking the alpha-heterocyclic carbonyl compound as a raw material, adding a bromination reagent, a solvent and a small molecular catalyst, and reacting under light irradiationto obtain a corresponding product. The method has the advantages of high yield, simplicity and convenience in operation, mild reaction conditions, wide substrate adaptability and the like.

Synthesis and cyclization reaction of pyrazolin-5-one derivatives

A versatile synthetic method for preparing 3-pyrazolin-5-ones and 5,8-dihydro-1H-pyrazolo[1,2-a]pyridazines from simple β-keto esters is demonstrated. The synthetic strategies involve the acylation of β-keto esters, cyclocondensation with hydrazine followed by trapping with a diene under oxidative conditions.

Synthesis and Some Reactions of 3-Methyl-2-pyrazolin-4,5-dione

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