33556-21-7Relevant academic research and scientific papers
Studies with 2-Arylhydrazono-3-oxopropanals: A novel route to 4-aroyl-2-aryl-1,2,3-triazoles, 3-substituted 4-arylazopyrazoles, 2-substituted glyoxalonitrile and 3-oxoalkanonitriles
Abdel-Khalik, Mervat Mohammed,Agamy, Samia Michel,Elnagdi, Mohammed Hilmy
, p. 1211 - 1215 (2000)
2-Arylhydrazono-3-oxopropanals 1 react with hydroxylamine hydrochloride to yield the corresponding oximes 3 that are cyclized into isoxazoles 9 on reflux in acetic anhydride and are converted into 2-arylhydrazono-3-oxonitriles (4) on treatment with pyridine. The reaction of 1 with hydrazines afforded dihydrazones 10 which were converted to arylazopyrazoles 11 when treated with pyridine, whereas treatment with an acidic reagent resulted in the formation of 3-aroyl-2-phenyl-1,2,3-triazoles 12.
A facile synthesis of formazan dyes conjugated with plasmonic nanoparticles as photosensitizers in photodynamic therapy against leukemia cell line
Khalifa, Mohamed E.,Elkhawass, Elham A.,Pardede, Antoni,Ninomiya, Masayuki,Tanaka, Kaori,Koketsu, Mamoru
, p. 2195 - 2206 (2018)
Abstract: A series of 1,5-bis(4-aryl/heteryl)-3-cyanoformazan derivatives was synthesized and characterized by spectral analysis. The synthesis strategy involved an easy and practical diazo coupling of different aryl (heteryl) diazonium salts with cyanoacetic acid. The synthesized compounds were electrostatically conjugated to gold and/or silver nanoparticles in dimethylsulfoxide and were examined as photosensitizers for photodynamic therapy (PDT). The PDT activity of the formazan derivatives alone and conjugated with metal nanoparticles was investigated against HL-60 cells under dark and light conditions. Formazan derivatives and their conjugates showed variable promising anticancer activity in dark and light conditions related to their structures. The interaction of synthesized formazan derivatives with metal nanoparticles enhanced the light absorption of the dyes and thus showed remarkable increase in PDT against cancer cells. Graphical abstract: [Figure not available: see fulltext.].
Reactions of Methylenedisulfonyldi(acetic acid) Derivatives with Arenediazonium Salts and Aromatic Aldehydes
Bazavova, I. M.,Esipenko, A. N.,Neplyuev, V. M.,Lozinskii, M. O.
, p. 520 - 524 (2007/10/03)
Reactions of methylenedisulfonyldiacetonitrile with arenediazonium salts in weakly alkaline medium yield mixtures of 1,5-bis(arylhydrazono)-1,5-dicyano-2,4-dithiapentane 2,2,4,4-tetraoxides and 1,5-diaryl-3-cyanoformazans.Under the same conditions, dimethyl methylenedisulfonyldiacetate yields mainly 1,5-bis(arylhydrazono)-1,5-bis(methoxycarbonyl)-2,4-dithiapentane 2,2,4,4-tetraoxides, whereas methylenedisulfonyldiacetamide reacts with elimination of the carbamoyl groups to give 1,1',5,5'-tetraaryl-3,3'-methylenedisulfonyldiformazans.Methylenedisulfonyldiacetonitrile reacts with aromatic aldehydes with formation of 1,7-diaryl-2,6-dicyano-3,5-dithia-1,6-heptadiene 3,3,5,5-tetraoxides.
