335595-77-2

Upstream product

• 380611-23-4 [1-13C]-1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-furanoside 
• 144963-49-5 C₃₇⁽¹³⁾CH₂₉N₅O₈ 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 335595-71-6 D-[1'-13C]-3',5'-O-(di-tert-butylsilanediyl)-N⁶-benzoyladenosine 
• 144963-49-5 [1'-13C]-2',3',5'-tri-O-benzoyl-N⁶-benzoyladenosine 
• 335595-67-0 [1'-13C]-N⁶-benzoyladenosine 
• 18055-47-5 N-Benzoyl-N,9-bis(trimethylsilyl)adenin 
• 4005-49-6 N-benzoyladenine 
• 335595-71-6 [1'-13C]-3',5'-O-(di-tert-butylsilanediyl)-N⁶-benzoyladenosine 
• 380611-22-3 Methyl <1-(13)C>-D-ribofuranoside 
• 335595-67-0 C₁₆⁽¹³⁾CH₁₇N₅O₅ 
• 83866-07-3 1-O-methyl-D-[1-13C]ribofuranoside 

Downstream Products

• 335595-83-0 C₄₃⁽¹³⁾CH₄₉N₅O₇Si 
• 335595-80-7 D-[1'-13C]-2'-O-tert-butyldimethylsilyl-N⁶-benzoyladenosine 
• 335595-83-0 [1'-13C]-5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N⁶-benzoyladenosine 
• 335595-80-7 [1'-13C]-2'-O-tert-butyldimethylsilyl-N⁶-benzoyladenosine 

Relevant academic research and scientific papers

Efficient synthesis of D-[1′-13c]-ribonucleosides for incorporation into oligo-RNA

Syntheses of the monomer building blocks used for the solid-phase synthesis of specifically 1′-13C-labeled oligoribonucleotides from the D-[1-13C]ribose is presented. Procedure has been used for the selective formation of 2′-O-silylated ribonucleosides. After 5′-O-dimethoxytritylation, the synthesis of D-[1′-13C] ribonucleoside phosphoramidites has been achieved.

Synthesis of isotopically labeled D-[1′-13C]ribonucleoside phosphoramidites

The preparation of fully protected labeled diisopropylamino-β-cyanoethyl-[1′-13C]ribonucleoside phosphoramidites with regioisomeric purity is described. We demonstrated in this paper that a regioselective 2′-O-silylation, through a 3′,5′-O-di-tert-butylsilanediyl protection, has been applied for the synthesis of [1′-13C]ribonucleoside phosphoramidite units. This method allowed us to obtain only the desired 2′-O-silyl-3′-O-phosphoramidites avoiding the undesired 3′-O-silyl-2′-O-phosphoramidite nucleosides isolated by standard procedures. This is a suitable procedure to RNA precursors with respect to the isotope-containing precursors.