335612-71-0

Upstream product

• 121-43-7 Trimethyl borate 
• 1645-24-5 2,4-dicarboxy-4'-fluoro-benzophenone 
• 459-57-4 4-fluorobenzaldehyde 
• 1645-26-7 2-(4'-fluorobenzoyl)terephthalic acid 

Downstream Products

• 64169-67-1 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile 
• 335612-72-1 1-(4-fluorophenyl)-1,3-dihydroisobenzofurane-5-formaldehyde 
• 361343-34-2 5-bromomethyl-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran 

Relevant academic research and scientific papers

PRODUCTION METHOD OF CITALOPRAM, INTERMMEDIATE THEREFOR AND PRODUCTION METHOD OF THE INTERMEDIATE

Citalopram can be industrially and economically produced and at a high yield by reacting a compound of the following formula [VI] with 3-(dimethylamino)propyl chloride in the presence of at least one of N,N,N′,N′-tetramethylethylenediamine and 1,3-dimethyl-2-imidazolidinone and a condensing agent. The compound of the following formula [III], which is a key compound for the production of citalopram, can be easily produced by subjecting the compound of the following formula [II] to reduction and cyclization. 1

Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate

The present invention provides a production method of a 5-phthalancarbonitrile compound, which comprises the use of a novel compound of the formula [I] wherein X is chlorine atom, bromine atom or iodine atom, as a key intermediate; intermediate; and the process of preparing intermediates.