335612-72-1Relevant academic research and scientific papers
PRODUCTION METHOD OF CITALOPRAM, INTERMMEDIATE THEREFOR AND PRODUCTION METHOD OF THE INTERMEDIATE
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, (2008/06/13)
Citalopram can be industrially and economically produced and at a high yield by reacting a compound of the following formula [VI] with 3-(dimethylamino)propyl chloride in the presence of at least one of N,N,N′,N′-tetramethylethylenediamine and 1,3-dimethyl-2-imidazolidinone and a condensing agent. The compound of the following formula [III], which is a key compound for the production of citalopram, can be easily produced by subjecting the compound of the following formula [II] to reduction and cyclization. 1
Method for the preparation of citalopram
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, (2008/06/13)
A method for the preparation of citalopram wherein the aldehyde of formula is converted to the corresponding 5-cyano compound of formula (I) which is alkylated to form citalopram, which is isolated in the form of the base or an acid addition salt thereof.
