335634-69-0

Upstream product

• 335101-39-8 2-Hydroxy-1-((2S,4S)-6-hydroxy-4-methyl-tetrahydro-pyran-2-yl)-2-methyl-propan-1-one 
• 443883-61-2 (2R,4S,5S)-4,5-di[(tert-butyldimethylsilyl)oxy]-1-(phenylsulfonyl)-2-methylheptan-6-one 
• 335101-34-3 (2R,4S,5S)-4,5-di[(tert-butyldimethylsilyl)oxy]-1-hydroxy-2-methylheptan-6-one 
• 335101-32-1 (2R,4S,5S)-4,5-di[(tert-butyldimethylsilyl)oxy]-2-methyl-6-oxy-heptaldehyde 
• 335101-43-4 2-[(2S,4S)-4,5,6-trihydroxy-2,6-dimethylheptyl]-1,3-dithiane 
• 443883-40-7 (4S,6S)-2-methyloxy-4-methyl-6-(2'-hydroxy-2'-methylpropionyl)-tetrahydropyran 
• 335101-41-2 1-((2S,4S)-6-Methoxy-4-methyl-tetrahydro-pyran-2-yl)-2-methyl-propane-1,2-diol 
• 873-55-2 sodium benzenesulfonate 
• 335101-24-1 (3S,5S)-5,6-di[(tert-butyldimethylsilyl)oxy]-3,7-dimethyl-7-octenal 
• 335101-22-9 (2R,4S,5S)-4,5-di[(tert-butyldimethylsilyl)oxy]-6,6-diethyloxy-1-(phenylsulfonyl)-2-methylheptane 

Downstream Products

• 443883-68-9 (3S,4S,6R,10S,12S)-7-Benzenesulfonyl-3,4,12,13-tetrakis-(tert-butyl-dimethyl-silanyloxy)-6,10,14-trimethyl-pentadec-14-ene-2,8-dione 

Relevant academic research and scientific papers

A convergent synthesis of the spiroketal moiety of the HIV-1 protease inhibitors didemnaketals

The stereoselective synthesis of the spiroketal fragment 4a and its C1″-epimer 4b of the HIV-1 protease inhibitors didemnaketals has been carried out through multisteps from the natural (R)-(+)-pulegone, which involved the diastereoselective construction of four chiral carbon centers by intramolecular chiral induction.

Synthetic studies of the HIV-1 protease inhibitive didemnaketals: stereocontrolled synthetic approach to the key mother spiroketals.

The stereocontrolled synthesis of (2S,4R,6R,8S,10S,1'R,1' 'R)-2(acetylhydroxymethyl)-4,10-dimethyl-8(isopropenylhydroxymethyl)-1,7-dioxaspiro[5,5]undecane (4a) and its C1' '-epimer (4b), the key mother spiroketals of the HIV-1 protease inhibitive didemnaketals from the ascidian Didemnum sp., has been carried out through multisteps from the natural (R)-(+)-pulegone, which involved the diastereoselective construction of four chiral carbon centers(C-2, C-6, C-8, and C-1') by intramolecular chiral induce.