443883-61-2

Upstream product

• 873-55-2 sodium benzenesulfonate 
• 335101-32-1 (2R,4S,5S)-4,5-di[(tert-butyldimethylsilyl)oxy]-2-methyl-6-oxy-heptaldehyde 
• 335101-34-3 (2R,4S,5S)-4,5-di[(tert-butyldimethylsilyl)oxy]-1-hydroxy-2-methylheptan-6-one 

Downstream Products

• 335634-69-0 (4S,6R,10R,12S,13S)-9-Benzenesulfonyl-3,4,12,13-tetrakis-(tert-butyl-dimethyl-silanyloxy)-14,14-diethoxy-2,6,10-trimethyl-pentadec-1-en-8-ol 
• 443883-68-9 (3S,4S,6R,10S,12S)-7-Benzenesulfonyl-3,4,12,13-tetrakis-(tert-butyl-dimethyl-silanyloxy)-6,10,14-trimethyl-pentadec-14-ene-2,8-dione 

Relevant academic research and scientific papers

A convergent synthesis of the spiroketal moiety of the HIV-1 protease inhibitors didemnaketals

The stereoselective synthesis of the spiroketal fragment 4a and its C1″-epimer 4b of the HIV-1 protease inhibitors didemnaketals has been carried out through multisteps from the natural (R)-(+)-pulegone, which involved the diastereoselective construction of four chiral carbon centers by intramolecular chiral induction.

Synthetic studies of the HIV-1 protease inhibitive didemnaketals: stereocontrolled synthetic approach to the key mother spiroketals.

The stereocontrolled synthesis of (2S,4R,6R,8S,10S,1'R,1' 'R)-2(acetylhydroxymethyl)-4,10-dimethyl-8(isopropenylhydroxymethyl)-1,7-dioxaspiro[5,5]undecane (4a) and its C1' '-epimer (4b), the key mother spiroketals of the HIV-1 protease inhibitive didemnaketals from the ascidian Didemnum sp., has been carried out through multisteps from the natural (R)-(+)-pulegone, which involved the diastereoselective construction of four chiral carbon centers(C-2, C-6, C-8, and C-1') by intramolecular chiral induce.