33581-98-5

Basic information

• Product Name: PYRIMIDIN-4-YL-METHANOL
• Synonyms: 4-(HYDROXYMETHYL)PYRIMIDINE;4-PYRIMIDINEMETHANOL;RARECHEM AK ML 0568;PYRIMIDIN-4-YL-METHANOL;4-Pyrimidinemethanol (9CI);(PYRIMIDIN-4-YL)METHANOL,PURITY:95% MIN(HPLC);4-(Hydroxymethyl)pyrimidi...;(Pyrimidin-4-yl)methanol, 4-(Hydroxymethyl)-1,3-diazine
• CAS NO: 33581-98-5
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 33581-98-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 75-78℃
• Boiling Point: 250.784 °C at 760 mmHg
• Flash Point: 105.47 °C
• Appearance: /
• Density: 1.228 g/cm³
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 13.41±0.10(Predicted)
• CAS DataBase Reference: PYRIMIDIN-4-YL-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIMIDIN-4-YL-METHANOL(33581-98-5)
• EPA Substance Registry System: PYRIMIDIN-4-YL-METHANOL(33581-98-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 33581-98-5(Hazardous Substances Data)

Usage

General Description

PYRIMIDIN-4-YL-METHANOL is a chemical compound with the molecular formula C5H6N2O. It is a derivative of pyrimidine, a six-membered ring structure containing four carbon atoms and two nitrogen atoms. PYRIMIDIN-4-YL-METHANOL has a hydroxyl group attached to the pyrimidine ring, giving it both basic and alcohol properties. It is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. PYRIMIDIN-4-YL-METHANOL is also used as a reagent in organic synthesis and as a precursor in the production of various useful chemicals. PYRIMIDIN-4-YL-METHANOL is an important intermediate in the field of medicinal chemistry and has potential applications in drug discovery and development.

InChI:InChI=1/C5H6N2O/c8-3-5-1-2-6-4-7-5/h1-2,4,8H,3H2

Upstream product

• 2450-08-0 methyl pyrimidine-4-carboxylate 
• 68229-92-5 4-pyrimidinecarboxaldehyde hydrazone 
• 49689-16-9 triazolo<1,5-c>pyrimidine 
• 289-95-2 PYRIMIDINE 
• 67-56-1 methanol 

Downstream Products

• 54198-78-6 4-(bromomethyl)pyrimidine 
• 845907-72-4 ethyl 2-[(diphenylmethylidene)amino]-3-(pyrimidin-4-yl)propanoate 
• 1351764-54-9 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(pyrimidin-4-ylmethoxy)nicotinamide 

Relevant articles and documents

Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity

Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosoma cruzi, is an important drug target for Chagas disease. We describe here a new series of reversible but time-dependent inhibitors of cruzain, composed of a dipeptide scaffold appended to vinyl heterocycles meant to provide replacements for the irreversible reactive "warheads" of vinyl sulfone inactivators of cruzain. Peptidomimetic vinyl heterocyclic inhibitors (PVHIs) containing Cbz-Phe-Phe/homoPhe scaffolds with vinyl-2-pyrimidine, vinyl-2-pyridine, and vinyl-2-(N-methyl)-pyridine groups conferred reversible, time-dependent inhibition of cruzain (Ki? = 0.1-0.4 μM). These cruzain inhibitors exhibited moderate to excellent selectivity versus human cathepsins B, L, and S and showed no apparent toxicity to human cells but were effective in cell cultures of Trypanosoma brucei brucei (EC50 = 1-15 μM) and eliminated T. cruzi in infected murine cardiomyoblasts (EC50 = 5-8 μM). PVHIs represent a new class of cruzain inhibitors that could progress to viable candidate compounds to treat Chagas disease and human sleeping sickness.

The chemistry of [1,2,3]triazolo[1,5-c]pyrimidine

Reactions of [1,2,3]triazolo[1,5-c]pyrimidine 2 with some electrophiles and nucleophiles are reported. Triazole ring opening and loss of nitrogen is the principal reaction with electrophiles. With strong acids protonation on N6 competes successfully. Derivatives in which the pyrimidine ring has been opened are obtained in reactions with nucleophiles. No stable simple substitution compounds were found.