33584-91-7Relevant academic research and scientific papers
Comparative α- and β-adrenoceptor activity of 2- and 6-ring-chlorinated noradrenaline analogues
Squier,Van der Schyf,Oliver,Venter
, p. 457 - 460 (2007/10/02)
The α- and β-adrenoceptor activity of the 2- and 6-ring-chlorinated analogues of noradrenaline (norepinephrine) were evaluated in vitro. The 2-chloro-substituted analogue exhibits a far greater affinity for β1-chronotropic receptors than the 6-chloro-substituted analogue, whereas no significant differences are apparent for their α-adrenergic affinities.
HALOGEN SUBSTITUTED ALPHA-(AMINOALKYL)-3,4-DIHYDROXYBENZYL ALCOHOLS
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, (2008/06/13)
Halogen substituted α-(aminoalkyl)-3,4-dihydroxybenzyl alcohols having β-adrenergic stimulant activity, particularly as selective bronchodilators. The α-aminomethyl derivatives are prepared by the condensation of an appropriately substituted styrene oxide with a primary amine followed by removal of the ether protective group(s). The α-aminoethyl or α-aminopropyl derivatives are prepared by the condensation of an appropriately substituted α-bromoalkyl phenyl ketone with an N-benzyl secondary amine followed by reduction of the ketone moiety and removal of the ether protective group(s).
