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2-Chloroveratraldehyde, also known as 2-chloro-3,4-dihydroxybenzaldehyde, is a chemical compound with the molecular formula C8H7ClO3. It is a chlorinated aldehyde derivative of veratraldehyde, which is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 2-Chloroveratraldehyde has been studied for its potential antifungal and antimicrobial properties and has also been investigated for its potential use as a starting material for the preparation of various biologically active compounds. Its synthesis and reactivity have been the subject of research in the field of organic chemistry, particularly in the development of new synthetic methodologies for the preparation of complex molecules.

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  • 18093-05-5 Structure
  • Basic information

    1. Product Name: 2-Chloroveratraldehyde
    2. Synonyms: 2-Chloro-4,5-dimethoxybenzaldehyde;2-chloro-4,5-dimethoxybenzaldehyde(SALTDATA: FREE)
    3. CAS NO:18093-05-5
    4. Molecular Formula: C9H9ClO3
    5. Molecular Weight: 200.61896
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 18093-05-5.mol
  • Chemical Properties

    1. Melting Point: 144 °C
    2. Boiling Point: 303.6 °C at 760 mmHg
    3. Flash Point: 132.3 °C
    4. Appearance: /
    5. Density: 1.245 g/cm3
    6. Vapor Pressure: 0.000923mmHg at 25°C
    7. Refractive Index: 1.549
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-Chloroveratraldehyde(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-Chloroveratraldehyde(18093-05-5)
    12. EPA Substance Registry System: 2-Chloroveratraldehyde(18093-05-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: R36/37/38:Irritating to eyes, respiratory system and skin.;
    3. Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 18093-05-5(Hazardous Substances Data)

18093-05-5 Usage

Uses

Used in Pharmaceutical Industry:
2-Chloroveratraldehyde is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for the creation of a wide range of compounds with potential medicinal applications.
Used in Agrochemical Industry:
2-Chloroveratraldehyde is used as a starting material for the preparation of agrochemicals, specifically in the development of new pesticides and other agricultural chemicals. Its potential antifungal and antimicrobial properties make it a valuable component in the formulation of effective crop protection products.
Used in Organic Chemistry Research:
2-Chloroveratraldehyde is used as a subject of study in the field of organic chemistry, particularly in the development of new synthetic methodologies. Its reactivity and potential for forming complex molecules make it an important compound for advancing the understanding of chemical reactions and the creation of novel chemical entities.

Check Digit Verification of cas no

The CAS Registry Mumber 18093-05-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,0,9 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 18093-05:
(7*1)+(6*8)+(5*0)+(4*9)+(3*3)+(2*0)+(1*5)=105
105 % 10 = 5
So 18093-05-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H9ClO3/c1-12-8-3-6(5-11)7(10)4-9(8)13-2/h3-5H,1-2H3

18093-05-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-4,5-dimethoxybenzaldehyde

1.2 Other means of identification

Product number -
Other names 6-chloroverataldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18093-05-5 SDS

18093-05-5Relevant articles and documents

Structure of 4-(2-chloro-4,5-dimethoxybenzylidene)-2-methyl-5-oxazolone. X-ray and NMR study

Haasbroek,Oliver,Carpy

, p. 811 - 814 (1998)

The azlactone of 6-chloroveratraldehyde 3 (4-(2-chloro-4,5-dimethoxybenzylidene)-2-methyl-5-oxazolone) was synthesized from 6-chloroveratraldehyde 2 and its structure investigated using X-ray crystallographic and nuclear magnetic resonance methods. Compound 3 crystallized in the P21/c (#14) space group (Z = 4) with cell dimensions a = 9.148(2), b = 22.938(2), c = 6.707(1) A, and β = 111.50(2)°. The X-ray study shows that azlactone 3 exists as the Z-isomer and crystallizes as a planar structure, i.e., both the phenyl and azlactone ring systems, as well as the functional groups attached to them, lie in the same plane. The 1H and 13C NMR spectral values also support the formation of the Z-isomer only, during the synthesis of 4-(2-chloro-4,5-dimethoxybenzylidene)-2-methyl-5-oxazolone.

Monodentate Transient Directing Group Enabled Pd-Catalyzed Ortho-C-H Methoxylation and Chlorination of Benzaldehydes

Li, Feng,Zhou, Yirong,Yang, Heng,Wang, Ziqi,Yu, Qinqin,Zhang, Fang-Lin

supporting information, p. 3692 - 3695 (2019/05/24)

We report Pd-catalyzed ortho-C-H methoxylation and chlorination of benzaldehydes by employing monodentate transient directing groups (TDGs) as an alternative strategy to bidentate TDGs. More importantly, a single crystal of benzaldehyde imine ortho-cyclopalladium intermediate was successfully obtained, and its structure was unambiguously determined by X-ray diffraction, which clearly showed that it was a binuclear palladium species bridged by a pyridone ligand. The utility of this approach was further demonstrated through the synthesis of key intermediates of natural products and drugs.

Diverse ortho-C(sp2)-H functionalization of benzaldehydes using transient directing groups

Liu, Xi-Hai,Park, Hojoon,Hu, Jun-Hao,Hu, Yan,Zhang, Qun-Liang,Wang, Bao-Long,Sun, Bing,Yeung, Kap-Sun,Zhang, Fang-Lin,Yu, Jin-Quan

supporting information, p. 888 - 896 (2017/05/16)

Pd-catalyzed C-H functionalizations promoted by transient directing groups remain largely limited to C-H arylation only. Herein, we report a diverse set of ortho-C(sp2)-H functionalizations of benzaldehyde substrates using the transient directing group strategy. Without installing any auxiliary directing group, Pd(II)-catalyzed C-H arylation, chlorination, bromination, and Ir(III)-catalyzed amidation, could be achieved on benzaldehyde substrates. The transient directing groups formed in situ via imine linkage can override other coordinating functional groups capable of directing C-H activation or catalyst poisoning, significantly expanding the scope for metal-catalyzed C-H functionalization of benzaldehydes. The utility of this approach is demonstrated through multiple applications, including late-stage diversification of a drug analogue.

A straightforward and versatile protocol for the direct conversion of benzylic azides to ketones and aldehydes

González-Calderón, Davir,Morales-Reza, Marco A.,Díaz-Torres, Eduardo,Fuentes-Benítes, Aydeé,González-Romero, Carlos

, p. 83547 - 83550 (2016/10/12)

The synthesis of carbonyl compounds from benzylic azides through benzylideneamides is described for the first time. NaH-mediated activation of benzyl azides allows a rapid water-promoted oxidation under a facile protocol with good yields.

PYRAZOLO-HETEROARYL COMPOUNDS USEFUL TO TREAT TNF-ALPHA AND IL-1 MEDIATED DISEASES

-

Page/Page column 16-17, (2008/06/13)

A compound of formula (I) wherein the groups R1-R4, X and Y are as defined in the specification, useful to treat TNF-Alpha and IL-1 mediated diseases.

Comparative α- and β-adrenoceptor activity of 2- and 6-ring-chlorinated noradrenaline analogues

Squier,Van der Schyf,Oliver,Venter

, p. 457 - 460 (2007/10/02)

The α- and β-adrenoceptor activity of the 2- and 6-ring-chlorinated analogues of noradrenaline (norepinephrine) were evaluated in vitro. The 2-chloro-substituted analogue exhibits a far greater affinity for β1-chronotropic receptors than the 6-chloro-substituted analogue, whereas no significant differences are apparent for their α-adrenergic affinities.

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