33599-07-4Relevant articles and documents
A two-acetyl glycerin monostearate preparation method (by machine translation)
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Paragraph 0021; 0022; 0023; 0024; 0025; 0026; 0027; 0028, (2018/11/03)
The present invention provides a two-acetyl glycerin monostearate preparation method, comprises the following steps: using toluene as a reaction solvent, the glycerin monostearate and acetic anhydride according to 1:2 - 4 molar ratio is added to the bottle, in the presence of acid catalysis of the 110 - 120 °C reflux reaction, side reaction side water diversion, after the reaction the solvent is removed by rotary evaporation, the resulting saturated sodium carbonate aqueous solution residue for repeated washing, then with anhydrous sodium sulfate dehydration and drying to obtain b b [...] crude glycerol stearate; the obtained crude product using silica gel column chromatography to separate and purify, and then the rotation of the pressure under the conditions of the solvent is removed by evaporation, to obtain high-purity of the b b [...] stearic acid glyceride. This method is simple in operation, safety, environmental hazard, the resulting product has high purity, can meet the quality requirements of the pharmaceutical excipients. (by machine translation)