336-06-1Relevant academic research and scientific papers
SYNTHESIS OF FLUORINATED α-DIKETONES AND SOME INTERMEDIATES
Hudlicky, M.
, p. 383 - 406 (1981)
Reactions of perfluoroalkylcopper compounds with α-ketoacyl chlorides were used for the synthesis of fluorinated α-diketones.Heptafluoropropylcopper prepared from copper bronze and 1-iodoheptafluoropropane reacted with benzoylformyl chloride to give heptafluoro-1-phenyl-1,2-pentanedione, with trimethylpyruvyl chloride to give 2,2-dimethyl-5,5,6,6,7,7,7-heptafluoro-3,4-heptanedione, and with 3,3,4,4,5,5,5-heptafluoro-2-keto-pentanoyl chloride or oxalyl chloride to give tetradecafluoro-4,5-octane-dione.Syntheses of fluorinated acetylenes, cyanohydrins, α-hydroxy acids, α-keto acids, their chlorides, and other intermediates for the syntheses of α-diketones by the above route and by other methods are described.An interesting seven-membered ring containing β-hydroxy ketone was obtained by an intramolecular aldol condensation of a fluorinated bis(methyl) ketone.
Method for preparing fluorine-containing dihydric alcohol from fluorine-containing cycloolefin
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Paragraph 0048, (2021/07/01)
The invention discloses a method for preparing fluorine-containing dihydric alcohol from fluorine-containing cycloolefin. The method comprises the following steps: oxidizing fluorine-containing cycloolefin serving as a raw material by using an oxidizing agent and treating the fluorine-containing cycloolefin by using a strong alkali to generate a solid mixed salt containing corresponding fluorine-containing dicarboxylate, and then generating corresponding fluorine-containing binary acyl chloride under the action of an acylating chlorination reagent; and finally, enabling the fluorine-containing binary acyl chloride and a reducing agent to be subjected to a reduction reaction under the action of a solvent and a catalyst to obtain the corresponding fluorine-containing dihydric alcohol. The specific organic solvent and catalyst are adopted, and other conditions are matched, so that the fluorine-containing cycloolefin can be effectively promoted to generate corresponding fluorine-containing dihydric alcohol with high efficiency and high yield. The method has the advantages of easily available raw materials, simple process, convenience in operation, low cost and the like, and is suitable for large-scale production of fluorine-containing dihydric alcohol.
