355-74-8

Basic information

• Product Name: 2,2,3,3,4,4,5,5-OCTAFLUORO-1,6-HEXANEDIOL
• Synonyms: 2,2,3,3,4,4,5,5-OCTAFLUORO-1,6-HEXANEDIOL 98%;1H,1H,6H,6H-Perfluorohexane-1,6-diol;2,2,3,3,4,4,5,5-Octafluorohexane-1,6-diol 98%;2,2,3,3,4,4,5,5-Octafluorohexane-1,6-diol98%;2,2,3,3,4,4,5,5-OCTAFLUORO-1,6-HEXANEDIOL,99%;1,6-Hexanediol, 2,2,3,3,4,4,5,5-octafluoro-;1,6-DIHYDROXY-2,2,3,3,4,4,5,5-OCTAFLUOROHEXANE;2,2,3,3,4,4,5,5-OCTAFLUORO-1,6-HEXANEDIOL
• CAS NO: 355-74-8
• Molecular Formula: C₆H₆F₈O₂
• Molecular Weight: 262.1
• EINECS: -0
• Product Categories: Fluorous Chemistry;Fluorous Compounds;Synthetic Organic Chemistry;Alcohols;Monomers;Polymer Science
• Mol File: 355-74-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 66-70 °C(lit.)
• Boiling Point: 100 °C3 mm Hg(lit.)
• Flash Point: 100°C/3mm
• Appearance: white to off-white crystalline solid
• Density: 1.4712 (estimate)
• Vapor Pressure: 0.00155mmHg at 25°C
• Refractive Index: 1.331
• PKA: 12.62±0.10(Predicted)
• Water Solubility: Soluble in water.
• Stability: Stable. Incompatible with strong bases, strong oxidizing agents.
• BRN: 1784039
• CAS DataBase Reference: 2,2,3,3,4,4,5,5-OCTAFLUORO-1,6-HEXANEDIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,3,3,4,4,5,5-OCTAFLUORO-1,6-HEXANEDIOL(355-74-8)
• EPA Substance Registry System: 2,2,3,3,4,4,5,5-OCTAFLUORO-1,6-HEXANEDIOL(355-74-8)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22
• Safety Statements: 22-24/25-37-26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 355-74-8(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white crystalline solid

Uses

2,2,3,3,4,4,5,5-Octafluoro-1,6-hexanediol is used as a pharmaceutical intermediate.

InChI:InChI=1/C6H6F8O2/c7-3(8,1-15)5(11,12)6(13,14)4(9,10)2-16/h15-16H,1-2H2

Upstream product

• 3107-98-0 dimethyl Octafluoroadipate 
• 336-06-1 octafluoroadipoyl chloride 
• 3492-11-3 1,6-Bis-methylmercapto-dodecafluor-hexan 
• 2367-86-4 1H,2H-decafluorocyclohexane 
• 336-08-3 perfluoroadipic acid 
• 376-50-1 diethyl perfluoroadipate 

Downstream Products

• 376-58-9 2,2,3,3,4,4,5,5-octafluoro-1,6-bis-(4-nitro-benzoyloxy)-hexane 
• 1400205-47-1 C₂₀H₁₂F₈N₂O₁₀ 
• 2264-01-9 (2,2,3,3,4,4,5,5-octafluoro-1,6-hexadiyl)di(acrylate) 
• 355-73-7 2,2,3,3,4,4,5,5-octafluorohexane-1,6-diamine 
• 1362739-69-2 C₂₂H₁₆F₈N₆ 
• 58191-47-2 2,2,3,3,4,4,5,5-octafluorohexane-1,6-ditosyl 
• 1071601-69-8 2-hydroxy-2-(4-methoxy-benzoyl)cyclohexanecarboxylic acid 2,2,3,3,4,4,5,5-octafluoro-6-hydroxy-hexyl ester 
• 1071601-70-1 2-hydroxy-2-(4-methoxy-benzoyl)cyclohexanecarboxylic acid 2,2,3,3,4,4,5,5-octafluoro-6-[2-hydroxy-2-(4-methoxy-benzoyl)cyclohexanecarbonyloxy]hexyl ester 
• 33619-83-9 1,6-bis-benzenesulfonyloxy-2,2,3,3,4,4,5,5-octafluoro-hexane 

Relevant articles and documents

Method for preparing fluorine-containing dihydric alcohol from fluorine-containing cycloolefin

The invention discloses a method for preparing fluorine-containing dihydric alcohol from fluorine-containing cycloolefin. The method comprises the following steps: oxidizing fluorine-containing cycloolefin serving as a raw material by using an oxidizing agent and treating the fluorine-containing cycloolefin by using a strong alkali to generate a solid mixed salt containing corresponding fluorine-containing dicarboxylate, and then generating corresponding fluorine-containing binary acyl chloride under the action of an acylating chlorination reagent; and finally, enabling the fluorine-containing binary acyl chloride and a reducing agent to be subjected to a reduction reaction under the action of a solvent and a catalyst to obtain the corresponding fluorine-containing dihydric alcohol. The specific organic solvent and catalyst are adopted, and other conditions are matched, so that the fluorine-containing cycloolefin can be effectively promoted to generate corresponding fluorine-containing dihydric alcohol with high efficiency and high yield. The method has the advantages of easily available raw materials, simple process, convenience in operation, low cost and the like, and is suitable for large-scale production of fluorine-containing dihydric alcohol.